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Louisville vs. California prediction: Why Louisville is favored to win men's college basketball matchup [12/30/2025]

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Written by Dave Garofolo

Get Louisville vs California predictions for college basketball Tuesday.

Louisville-California Predictions and Game Preview.
Louisville vs. California men's college basketball prediction for Tuesday, December 30, 2025.

California will face the favored Louisville in men's college basketball action at Haas Pavilion on Tuesday, starting at 9:00 PM ET.

Based on the latest simulations, Dimers' advanced college basketball model predicts Louisville as the most likely winner of the Louisville vs. California game.

This article offers an expanded analysis of Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

Louisville vs. California prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Tuesday's NCAA basketball game between Louisville and California 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Louisville a 75% chance of defeating California. Our predicted final score has Louisville winning 81-74.

According to our model, California (+9.5) has a 60% chance of covering the spread, while the 159.5-point over/under has a 53% chance of staying under.

 

Louisville vs. California odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

Bet Type Louisville California
Spread -9.5 (-102) +9.5 (-118)
Moneyline -425 +330
Total o159.5 (-110) u159.5 (-108)

All odds are correct at the time of publication and are subject to change.

Louisville vs. California picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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