Lafayette vs. Charlotte prediction: Why Charlotte is favored to win men's college basketball matchup [12/18/2025]

Charlotte will square off with Lafayette in men's college basketball action at Dale F. Halton Arena on Thursday, beginning at 7:00 PM ET.

Based on the latest simulation results, Dimers' advanced college basketball model predicts Charlotte as the most likely winner of the Lafayette vs. Charlotte game.

This article offers an expanded analysis of Thursday's matchup, including an expanded look at the predicted score, best bets and picks.

Lafayette vs. Charlotte prediction: Who will win and cover?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Thursday's NCAA basketball matchup between Lafayette and Charlotte 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Charlotte an 84% chance of defeating Lafayette. Our predicted final score has Charlotte winning 73-64.

According to our model, Lafayette (+10.5) has a 54% chance of covering the spread, while the 137.5-point over/under has an equal 50-50 chance of hitting.

Lafayette vs. Charlotte odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Lafayette vs. Charlotte picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: