Iowa vs. Iowa State prediction: Why Iowa State is favored to win men's college basketball matchup [12/11/2025]

Iowa State and Iowa will lock horns in men's college basketball action at James H. Hilton Coliseum on Thursday, starting at 8:00PM ET.

Based on the latest simulation results, Dimers' proven college basketball model predicts Iowa State as the most likely winner of the Iowa vs. Iowa State game.

This article offers further insights into Thursday's matchup, including an expanded look at the predicted score, best bets and picks.

Iowa vs. Iowa State prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Thursday's NCAA basketball game between Iowa and Iowa State 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Iowa State an 88% chance of defeating Iowa. Our predicted final score has Iowa State winning 77-65.

According to our model, Iowa State (-10.5) has a 58% chance of covering the spread, while the over/under total of 143.5 points has a 52% chance of going over.

Iowa vs. Iowa State odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Iowa vs. Iowa State picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: