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Iowa State vs. Purdue prediction: Why Purdue is favored to win men's college basketball matchup [12/6/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Iowa State vs Purdue predictions for college basketball Saturday.
Purdue will square off with Iowa State in men's college basketball action at Mackey Arena on Saturday, starting at 12:00PM ET.
Based on updated simulation results, Dimers' advanced college basketball model projects Purdue as the most likely winner of the Iowa State vs. Purdue game.
This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Iowa State vs. Purdue prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the outcome of Saturday's NCAA basketball game between Iowa State and Purdue 10,000 times as part of our men's college basketball predictions coverage.
Our independent predictive model currently gives Purdue a 65% chance of beating Iowa State. Our predicted final score has Purdue winning 79-74.
According to our model, Iowa State (+4.5) has a 51% chance of covering the spread, while the 154.5-point over/under has an equal 50-50 chance of hitting.
Iowa State vs. Purdue odds
We have sourced the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Iowa State | Purdue |
|---|---|---|
| Spread | +4.5 (-110) | -4.5 (-108) |
| Moneyline | +190 | -210 |
| Total | o154.5 (-110) | u154.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Iowa State vs. Purdue picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Iowa State +4.5 | -110 |
| Moneyline | Iowa State | +190 |
| Total | Under 154.5 | -105 |
According to our men's college basketball best bets, the top play to make on this game is Iowa State to win.
Iowa State vs. Purdue game-day updates and essential details
Saturday's men's college basketball matchup between Purdue and Iowa State at Mackey Arena is scheduled to commence at 12:00PM ET.
- Who: Iowa State vs. Purdue
- Date: Saturday, December 6, 2025
- Time: 12:00PM ET/9:00AM PT
- Venue: Mackey Arena
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Conclusion
We predict Purdue, with a 65% win probability, will likely beat Iowa State on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Iowa State vs. Purdue insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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