Iowa State vs. Purdue prediction: Why Purdue is favored to win men's college basketball matchup [12/6/2025]

Purdue will square off with Iowa State in men's college basketball action at Mackey Arena on Saturday, commencing at 12:00PM ET.

Based on updated simulations, Dimers' advanced college basketball model projects Purdue as the most likely winner of the Iowa State vs. Purdue game.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Iowa State vs. Purdue prediction: Who will win and cover?

Using innovative machine learning and data analysis, we have simulated the outcome of Saturday's NCAA basketball game between Iowa State and Purdue 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Purdue a 74% chance of beating Iowa State. Our predicted final score has Purdue winning 80-73.

According to our model, Purdue (-6.5) has a 51% chance of covering the spread, while the 153.5-point over/under has a 52% chance of going over.

Iowa State vs. Purdue odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Iowa State vs. Purdue picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: