Iona vs. St. John's prediction: St. John's favored to win men's college basketball matchup [12/13/2025]

St. John's will face Iona in men's college basketball action at Madison Square Garden on Saturday, beginning at 12:00PM ET.

Based on updated simulation results, Dimers' proven college basketball model projects St. John's as the most likely winner of the Iona vs. St. John's game.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Iona vs. St. John's prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the result of Saturday's NCAA basketball matchup between Iona and St. John's 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives St. John's a 98% chance of defeating Iona. Our predicted final score has St. John's winning 92-66.

According to our model, Iona (+27.5) has a 51% chance of covering the spread, while the over/under total of 159.5 points has a 54% chance of staying under.

Iona vs. St. John's odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Iona vs. St. John's picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: