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Iona vs. St. John's prediction: St. John's favored to win men's college basketball matchup [12/13/2025]

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Written by Dave Garofolo

Get Iona vs St. John's predictions for college basketball Saturday.

Iona-St. John's Predictions and Game Preview.
Iona vs. St. John's men's college basketball prediction for Saturday, December 13, 2025.

St. John's will face Iona in men's college basketball action at Madison Square Garden on Saturday, beginning at 12:00PM ET.

Based on updated simulation results, Dimers' proven college basketball model projects St. John's as the most likely winner of the Iona vs. St. John's game.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Iona vs. St. John's prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the result of Saturday's NCAA basketball matchup between Iona and St. John's 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives St. John's a 98% chance of defeating Iona. Our predicted final score has St. John's winning 92-66.

According to our model, Iona (+27.5) has a 51% chance of covering the spread, while the over/under total of 159.5 points has a 54% chance of staying under.

 

Iona vs. St. John's odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

Bet Type Iona St. John's
Spread +27.5 (-110) -27.5 (-110)
Moneyline +4000 -30030
Total o159.5 (-105) u159.5 (-105)

All odds are correct at the time of publication and are subject to change.

Iona vs. St. John's picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread Iona +27.5 -110
Moneyline Iona +4000
Total Under 159.5 -105

According to our men's college basketball best bets, the top play to make on this game is Under 159.5 total points.

 

Iona vs. St. John's game-day updates and essential details

Saturday's men's college basketball action between St. John's and Iona at Madison Square Garden is scheduled to commence at 12:00PM ET.

  • Who: Iona vs. St. John's
  • Date: Saturday, December 13, 2025
  • Time: 12:00PM ET/9:00AM PT
  • Venue: Madison Square Garden

Conclusion

We predict St. John's, with a 98% win probability, will likely beat Iona on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Iona vs. St. John's insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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