Indiana vs. Kentucky prediction: Kentucky favored to win men's college basketball matchup [12/13/2025]

Kentucky and Indiana will lock horns in men's college basketball action at Rupp Arena on Saturday, with tipoff at 7:30PM ET.

Based on updated simulation results, Dimers' advanced college basketball model predicts Kentucky as the most likely winner of the Indiana vs. Kentucky game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Indiana vs. Kentucky prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Saturday's NCAA basketball matchup between Indiana and Kentucky 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Kentucky a 64% chance of beating Indiana. Our predicted final score has Kentucky winning 81-77.

According to our model, Kentucky (-2.5) has a 62% chance of covering the spread, while the over/under total of 159.5 points has a 51% chance of staying under.

Indiana vs. Kentucky odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Indiana vs. Kentucky picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: