Illinois vs. Missouri prediction: Why Illinois is favored to win men's college basketball matchup [12/22/2025]

Missouri and Illinois will meet in men's college basketball action at Enterprise Center on Monday, with tipoff at 8:00 PM ET.

Based on updated simulations, Dimers' advanced college basketball model predicts Illinois as the most likely winner of the Illinois vs. Missouri game.

This article offers a closer look at Monday's matchup, including an expanded look at the predicted score, best bets and picks.

Illinois vs. Missouri prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Monday's NCAA basketball game between Illinois and Missouri 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Illinois a 76% chance of defeating Missouri. Our predicted final score has Illinois winning 80-72.

According to our model, Missouri (+9.5) has a 57% chance of covering the spread, while the 154.5-point over/under has a 53% chance of staying under.

Illinois vs. Missouri odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Illinois vs. Missouri picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: