Illinois vs. Missouri CBB Predictions and Odds - Dec 22, 2021

Missouri and Illinois lock horns in College Basketball action at Enterprise Center on Wednesday, with tipoff at 9:00PM EST.

Dimers' free betting picks for Illinois vs. Missouri, plus game predictions and best odds, are featured below.

Who will win Illinois vs. Missouri?

Based on high-tech computer power and data, Dimers.com has simulated Wednesday's Illinois-Missouri NCAA Basketball game 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives Illinois an 86% chance of beating Missouri.

MORE: Illinois vs. Missouri Simulated 10,000 Times

Point Spread, Moneyline and Over/Under

Missouri is currently the +14.5 underdog versus Illinois, with -105 at PointsBet the best odds available.

For the favored Illinois (-14.5) to cover the spread, BetMGM has the best odds on offer at -110.

BetMGM has the best moneyline odds for Missouri at +725. That means you can throw down $100 to profit $725, earning a total payout of $825, if it wins.

Meanwhile, DraftKings Sportsbook has the best moneyline odds for Illinois at -1000, where you can risk $1000 to win $100, for a total payout of $1100, if it comes out on top.

The Over/Under is set at 139 with DraftKings Sportsbook, which has the best odds for the Over at -105, while PointsBet has the best odds for the Under at -110.

As always, make sure you check all the sportsbooks that are available in your state for the best College Basketball odds and lines.

According to DimersBOT, Missouri (+14.5) is a 62% chance of covering the spread, while the 139-point Over/Under is considered an equal 50-50 chance of hitting.

MORE: Live Scores for All Major College Sports

Best Bets for Illinois vs. Missouri

• Spread: Missouri +14.5 at -105 with PointsBet (62% probability) 🔥
• Moneyline: Missouri Win at +725 with BetMGM (2.4% edge)
• Over/Under: Over 139 at -105 with DraftKings Sportsbook (50% probability)

When you see a 🔥, that means it's one of our best free picks of the day across all major pro and college sports.

While Illinois is more likely to win the game, according to DimersBOT, betting on Missouri moneyline is the best option due to the 2.4% edge identified when comparing our data-led probabilities to the betting odds.

Taking advantage of the edges published on Dimers.com is crucial to being a profitable bettor in the long run.

Illinois vs. Missouri Score Prediction

Dimers.com's predicted final score for Illinois vs. Missouri at Enterprise Center on Wednesday has Illinois winning 75-64.

Use our dynamic widget below to explore the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full coverage of Wednesday's Illinois-Missouri matchup, including pre-game predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates often, so check this article for any changes to our betting analysis before Illinois vs. Missouri on Wednesday December 22, 2021.

Best Betting Promo for Illinois vs. Missouri

Looking the best sportsbook promo for Illinois vs. Missouri? Join FanDuel Sportsbook today and get a risk-free first bet up to $1,000, which you can use on this game.

All you need to do is click or tap on this exclusive FanDuel Sportsbook link and create a new account – it's easy and takes less than 2 minutes.

Then, make your first deposit and place a bet up to $1,000 on Illinois vs. Missouri. If your bet doesn't win, FanDuel Sportsbook will refund it in site credit!

This offer is available to all new FanDuel Sportsbook users. How good is that!

Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Illinois vs. Missouri 2021 CBB Game Info

When does Missouri play Illinois in College Basketball?

• Date: Wednesday December 22, 2021
• Time: 9:00PM EST / 6:00PM PST
• Venue: Enterprise Center

Enjoy Dimers and want to keep the site free? Every time you sign up and bet with a sportsbook featured here, we get paid a small fee.

These fees help us keep Dimers free for everyone. So, if you like what you see, support us by joining one of our legal sports betting partners now.

Want more College Basketball analysis like this?

To get more NCAA Basketball betting previews like you've just read for Illinois vs. Missouri, all you've gotta do is visit our College Basketball Betting News page. It's that easy – they're all there!

We use the power of predictive analytics to find edges in the markets so we can publish the most comprehensive CBB betting previews out there. We're able to do this by comparing our in-house probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.