Holy Cross vs. Harvard prediction: Harvard favored to win men's college basketball matchup [12/20/2025]

Men's college basketball action continues on Saturday at 2:00 PM ET as Holy Cross locks horns with Harvard in men's college basketball action at Lavietes Pavilion.

Based on the latest simulations, Dimers' proven college basketball model predicts Harvard as the most likely winner of the Holy Cross vs. Harvard game.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Holy Cross vs. Harvard prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the outcome of Saturday's NCAA basketball game between Holy Cross and Harvard 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Harvard an 83% chance of defeating Holy Cross. Our predicted final score has Harvard winning 74-64.

According to our model, the bookmakers have got it right, and Holy Cross and Harvard each have a 50% chance of covering the spread, while the 137.5-point over/under has a 54% chance of going over.

Holy Cross vs. Harvard odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Holy Cross vs. Harvard picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: