Guardians vs. Yankees Prediction and Odds - Apr 22, 2022

The New York Yankees face the Cleveland Guardians in MLB action at Yankee Stadium on Friday, starting at 7:05PM ET.

The Yankees will have Jameson Taillon (0-1, 3.72 ERA) start, while the Guardians will counter with Eli Morgan (1-0, 4.50 ERA).

Dimers' top betting picks for Guardians vs. Yankees, plus game predictions and best odds, are featured in this article.

Who will win Guardians vs. Yankees?

Based on state-of-the-art computer power and data, Dimers.com has simulated Friday's Guardians-Yankees MLB game 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives the Yankees a 61% chance of defeating the Guardians.

More: Free Betting Analysis for Guardians vs. Yankees

Guardians vs. Yankees Game Odds

• Run Line: Yankees -1.5 (+110), Guardians +1.5 (-125)
• Moneyline: Yankees -170, Guardians +165
• Total: Over/Under 8 (-110/-105)

Run Line, Moneyline and Over/Under

The Yankees are -1.5 favorites versus the Guardians, with +110 at DraftKings Sportsbook the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at -125.

DraftKings Sportsbook currently has the best moneyline odds for the Yankees at -170, which means you can risk $170 to win $100, for a total payout of $270, if they get the W.

Elsewhere, Caesars Sportsbook currently has the best moneyline odds for the Guardians at +165, where you can bet $100 to profit $165, earning a total payout of $265, if they win.

The Over/Under sits at 8 with Caesars Sportsbook, which currently has the best odds for the Over at -110, while PointsBet currently has the best odds for the Under at -105.

As always, make sure you check the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 56% chance of covering the run line, while the 8-run Over/Under is a 59% chance of going Over.

More: Predictions for Every MLB Game

Best Bets for Guardians vs. Yankees

• Run Line: Guardians +1.5 @ -125 via FanDuel Sportsbook (56% probability)
• Moneyline: Guardians @ +165 via Caesars Sportsbook (1.5% edge)
• Total: Over 8 @ -110 via Caesars Sportsbook (59% probability) 🔥

Every time you see a 🔥, that means you've found one of our best free picks of the day across all major pro and college sports.

Dimers' best bets are based on world-class simulations and betting intelligence to help you make more informed decisions with the legal sportsbooks in your state.

While the Yankees are more likely to win the game, according to DimersBOT, betting on the Guardians moneyline is the best option due to the 1.5% edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published on Dimers.com is crucial to achieving long-term profitability.

Guardians vs. Yankees Betting Guide

Use our dynamic widget below to see the latest Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. NY Yankees, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Friday's Guardians-Yankees matchup, including pregame predictions, free picks, and live win probabilities.

Remember, DimersBOT updates frequently, so refresh this page for the latest betting analysis ahead of Guardians vs. Yankees on Friday April 22, 2022.

Best Sportsbook Offer for Guardians vs. Yankees

Do you want to bet on Cleveland vs. NY Yankees? Join FanDuel Sportsbook today and get a risk-free first bet up to $1,000, which you can use on Friday's Guardians-Yankees game.

Simply click or tap on this exclusive FanDuel Sportsbook link and create a new account – it's easy and takes less than 2 minutes.

Then, make your first deposit and place a bet up to $1,000 on Guardians vs. Yankees. If you don't win your bet, FanDuel Sportsbook will refund it in site credit!

This offer is available to all new FanDuel Sportsbook users. How good is that!

Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Guardians vs. Yankees 2022 Game Info

When do the Yankees play the Guardians?

• Date: Friday April 22, 2022
• Time: 7:05PM ET / 4:05PM PT
• Venue: Yankee Stadium

Looking to join an online sportsbook and start betting on MLB? We've reviewed the best available welcome offers for every legal betting state.

What MLB games are on today?

Now you've got the 411 on Guardians vs. Yankees, see the latest betting analysis for all upcoming MLB games in our MLB Bet Hub. There you can find probabilities and odds, as well as our best bets for every single MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Lastly, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds available.