Guardians vs. White Sox Prediction and Odds - May 11, 2022

The Chicago White Sox take on the Cleveland Guardians in MLB action at Guaranteed Rate Field on Wednesday, starting at 2:10PM ET.

Vince Velasquez (2-2, 3.97 ERA) will start for the White Sox, up against Aaron Civale (1-2, 9.45 ERA) for the Guardians.

Dimers' free betting picks for Guardians vs. White Sox, as well as game predictions and best odds, are detailed below.

Today's Cleveland vs. CHI White Sox betting preview is brought to you by PointsBet, which has an awesome 5x $100 Risk-Free Bets promo for new users.

Who will win Guardians vs. White Sox?

Based on state-of-the-art computer power and data, Dimers.com has simulated Wednesday's Guardians-White Sox MLB matchup 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, currently gives the White Sox a 54% chance of winning against the Guardians.

More: Full Betting Guide for Guardians vs. White Sox

Guardians vs. White Sox Current Odds

• Run Line: White Sox -1.5 (+158), Guardians +1.5 (-175)
• Moneyline: White Sox -125, Guardians +110
• Total: Over/Under 8.5 (-102/-110)

Run Line, Moneyline and Over/Under

The White Sox are -1.5 favorites against the Guardians, with +158 at FanDuel Sportsbook the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at -175.

DraftKings Sportsbook currently has the best moneyline odds for the White Sox at -125. That means you can risk $125 to win $100, for a total payout of $225, if they get the W.

Meanwhile, BetMGM currently has the best moneyline odds for the Guardians at +110, where you can bet $100 to profit $110, earning a total payout of $210, if they win.

The Over/Under sits at 8.5 with FanDuel Sportsbook, which currently has the best odds for the Over at -102, while DraftKings Sportsbook currently has the best odds for the Under at -110.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 62% chance of covering the run line, while the 8.5-run Over/Under is a 52% chance of going Over.

More: Predictions for Every MLB Matchup

Best Bets for Guardians vs. White Sox

• Run Line: White Sox -1.5 @ +158 via FanDuel Sportsbook
• Moneyline: White Sox @ -125 via DraftKings Sportsbook (54% probability)
• Total: Over 8.5 @ -102 via FanDuel Sportsbook (52% probability)

Dimers' best bets are based on detailed simulations and betting intelligence to help you make smarter decisions with the legal sportsbooks in America.

Even though the Guardians are more likely to cover the run line, our best bet of White Sox -1.5 is based on the expectation of that happening, according to DimersBOT, and the top odds available.

Guardians vs. White Sox Probabilities

Use our interactive widget below to explore the latest Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. CHI White Sox, and click or tap on See Matchup for more.

Dimers has full betting coverage of Wednesday's Guardians-White Sox matchup, including pregame predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so check this page for any changes to our betting analysis ahead of Guardians vs. White Sox on Wednesday May 11, 2022.

Get a Risk-Free Bet for Guardians vs. White Sox

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Guardians vs. White Sox 2022 Game Info

Wednesday's action between the White Sox and Guardians at Guaranteed Rate Field will begin at 2:10PM ET.

• Date: Wednesday May 11, 2022
• Time: 2:10PM ET / 11:10AM PT
• Venue: Guaranteed Rate Field

Want to join an online sportsbook and start betting on MLB? We've reviewed the best available sign-up offers for each and every legal betting state.

What other MLB games are on today?

The Guardians and White Sox aren't the only two MLB teams you can bet on. DimersBOT never stops and we've got picks and top bets for each and every MLB game in our MLB Bet Hub page.

Not only do we provide with you great predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Hell yeah it does!

While you're here, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds available.