Guardians vs. White Sox Prediction and Odds - May 10, 2022

The Chicago White Sox and Cleveland Guardians lock horns in MLB at Guaranteed Rate Field on Tuesday, starting at 8:10PM ET.

The White Sox will send Lucas Giolito (1-1, 3.20 ERA) to the mound, pitting him against Cal Quantrill (1-1, 3.54 ERA) for the Guardians.

Dimers' best betting picks for Guardians vs. White Sox, plus game predictions and best odds, are featured in this article.

Today's Cleveland vs. CHI White Sox betting analysis is sponsored by PointsBet, which has a 5x $100 Risk-Free Bets promo for new customers.

Who will win Guardians vs. White Sox?

Based on trusted computer power and data, Dimers.com has simulated Tuesday's Guardians-White Sox MLB matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, currently gives the White Sox a 57% chance of defeating the Guardians.

More: Guardians vs. White Sox Simulated 10,000 Times

Guardians vs. White Sox Odds

• Run Line: White Sox -1.5 (+120), Guardians +1.5 (-125)
• Moneyline: White Sox -179, Guardians +168
• Total: Over/Under 8 (-114/+100)

Run Line, Moneyline and Over/Under

The White Sox are -1.5 favorites versus the Guardians, with +120 at Caesars Sportsbook the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on the market at -125.

Caesars Sportsbook currently has the best moneyline odds for the White Sox at -179, which means you can risk $179 to win $100, for a total payout of $279, if they get the W.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the Guardians at +168, where you can bet $100 to profit $168, earning a total payout of $268, if they win.

The Over/Under for total runs scored is set at 8 with FanDuel Sportsbook, which currently has the best odds for the Over at -114, while DraftKings Sportsbook currently has the best odds for the Under at +100.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 61% chance of covering the run line, while the Over/Under total of 8 runs is a 53% chance of going Over.

More: Today's Best Bets for All Major Sports

Best Bets for Guardians vs. White Sox

• Run Line: Guardians +1.5 @ -125 via DraftKings Sportsbook (61% probability) 🔥
• Moneyline: Guardians @ +168 via FanDuel Sportsbook (6.0% edge) 🔥
• Total: Over 8 @ -114 via FanDuel Sportsbook (53% probability)

When you see a 🔥, that means you've found one of Dimers' best free picks of the day across all sports.

Dimers' best bets are based on complex simulations and wagering intelligence to serve you the best possible plays 24/7/365.

While the White Sox are more likely to win the game, according to DimersBOT, betting on the Guardians moneyline is the best option due to the 6.0% edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published on Dimers.com is one of the keys to being profitable in the long run.

Guardians vs. White Sox Probabilities

Use our dynamic widget below to view up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. CHI White Sox, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Tuesday's Guardians-White Sox matchup, including pregame predictions, free picks, and live updates.

Remember, DimersBOT updates often, so keep an eye on this article for the latest betting insights ahead of Guardians vs. White Sox on Tuesday May 10, 2022.

Best Betting Promo for Guardians vs. White Sox

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Guardians vs. White Sox 2022 Game Info

Tuesday's action between the White Sox and Guardians at Guaranteed Rate Field will commence at 8:10PM ET.

• Date: Tuesday May 10, 2022
• Time: 8:10PM ET / 5:10PM PT
• Venue: Guaranteed Rate Field

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What other MLB games are on today?

The Guardians and White Sox aren't the only two MLB teams you can bet on. DimersBOT never stops and we've got picks and best bets for every single MLB matchup in our MLB Bet Hub page.

Not only do we provide with you quality predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Hell yeah it does!

While you're here, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities paired with the best odds on the market.