Guardians vs. Twins Prediction and Odds - May 15, 2022

The Minnesota Twins face the Cleveland Guardians in MLB action at Target Field on Sunday, beginning at 2:10PM ET.

Joe Ryan (3-2, 2.56 ERA) will get the ball for the Twins, while the Guardians are going with Triston McKenzie (2-2, 2.76 ERA).

Dimers' top betting picks for Guardians vs. Twins, plus game predictions and best odds, are featured in this article.

Today's Cleveland vs. Minnesota betting preview is presented by PointsBet, which has a 5x $100 Risk-Free Bets promo for new customers.

Who will win Guardians vs. Twins?

Using high-tech machine learning and data, Dimers.com has simulated Sunday's Guardians-Twins MLB game 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives the Twins a 55% chance of winning against the Guardians.

More: Guardians vs. Twins Simulated 10K Times

Guardians vs. Twins Game Odds

• Run Line: Twins -1.5 (+145), Guardians +1.5 (-160)
• Moneyline: Twins -145, Guardians +125
• Total: Over/Under 7.5 (-110/+100)

Run Line, Moneyline and Over/Under

The Twins are -1.5 favorites versus the Guardians, with +145 at Caesars Sportsbook the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at -160.

Caesars Sportsbook currently has the best moneyline odds for the Twins at -145. That means you can risk $145 to win $100, for a total payout of $245, if they get the W.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the Guardians at +125, where you can bet $100 to profit $125, earning a total payout of $225, if they win.

The Over/Under sits at 7.5 with Caesars Sportsbook, which currently has the best odds for the Over at -110, while DraftKings Sportsbook currently has the best odds for the Under at +100.

As always, make sure you check all the legal sportbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 63% chance of covering the run line, while the Over/Under total of 7.5 runs is a 53% chance of going Over.

More: Live Win Probabilities for All Major Sports

Best Bets for Guardians vs. Twins

• Run Line: Guardians +1.5 @ -160 via DraftKings Sportsbook (63% probability)
• Moneyline: Guardians @ +125 via DraftKings Sportsbook (0.8% edge)
• Total: Over 7.5 @ -110 via Caesars Sportsbook (53% probability)

Dimers' best bets are based on complex simulations and wagering intelligence to help you make more informed decisions with the legal sportsbooks in your state.

While the Twins are more likely to win the game, according to DimersBOT, taking the Guardians moneyline is the best option due to the edge found when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges published here at Dimers is one of the keys to being profitable in the long run.

Guardians vs. Twins Betting Guide

Use our dynamic widget below to view the latest Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. Minnesota, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Sunday's Guardians-Twins matchup, including pregame predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so refresh this page for any changes to our betting analysis before Guardians vs. Twins on Sunday May 15, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Guardians vs. Twins 2022 Game Info

Sunday's action between the Twins and Guardians at Target Field is scheduled to begin at 2:10PM ET.

• Date: Sunday May 15, 2022
• Time: 2:10PM ET / 11:10AM PT
• Venue: Target Field

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Want more MLB previews like this?

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That's right, our predictive analytics model then compares those odds against its own probabilities to find value in the markets, which allows us to write the most accurate MLB betting previews and beat the public and the sportsbooks to the punch.

It's only a click away, so why not take a look around?

Finally, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.