Guardians vs. Twins Prediction and Odds - Jun 22, 2022

MLB action continues on Wednesday at 7:40PM ET as the Cleveland Guardians lock horns with the Minnesota Twins at Target Field.

Sonny Gray (3-1, 2.10 ERA) will be on the bump for the Twins, while the Guardians are going with Triston McKenzie (4-5, 2.96 ERA).

Dimers' best betting picks for Guardians vs. Twins, as well as game predictions and betting odds, are detailed below.

Who will win Guardians vs. Twins?

Based on state-of-the-art machine learning and data, Dimers.com has simulated Wednesday's Guardians-Twins MLB matchup 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, currently gives the Twins a 58% chance of getting the W against the Guardians.

More: Free Betting Analysis for Guardians vs. Twins

Guardians vs. Twins Odds

• Run Line: Twins -1.5 (+140), Guardians +1.5 (-150)
• Moneyline: Twins -155, Guardians +140
• Total: Over/Under 8 (-110/-102)

Run Line, Moneyline and Over/Under

The Twins are listed as -1.5 favorites against the Guardians, with +140 at Caesars Sportsbook the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, BetMGM has the best odds currently on offer at -150.

DraftKings Sportsbook currently has the best moneyline odds for the Twins at -155, which means you can risk $155 to win $100, for a total payout of $255, if they get the W.

Elsewhere, Caesars Sportsbook currently has the best moneyline odds for the Guardians at +140, where you can put down $100 to profit $140, earning a total payout of $240, if they win.

The Over/Under for total runs scored is set at 8 with DraftKings Sportsbook, which currently has the best odds for the Over at -110, while FanDuel Sportsbook currently has the best odds for the Under at -102.

As always, check out all the legal sportbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 59% chance of covering the run line, while the Over/Under total of 8 runs is a 58% chance of going Over.

More: Track Your Bets via Dimers' Bet Center

Best Bets for Guardians vs. Twins

• Run Line: Guardians +1.5 @ -150 via BetMGM (59% probability)
• Moneyline: Guardians @ +140 via Caesars Sportsbook (0.3% edge)
• Total: Over 8 @ -110 via DraftKings Sportsbook (58% probability) 🔥

If you see a 🔥, that means it's one of our best free picks of the day across all major pro and college sports.

Dimers' best bets are based on detailed simulations and gambling expertise to help you make more informed investments with your state's legal sportsbooks.

While the Twins are more likely to win the game, according to DimersBOT, taking the Guardians moneyline is the best option because of the edge found when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges seen here at Dimers.com is one of the keys to achieving long-term profitability as a sports bettor.

Guardians vs. Twins Prediction

Use our widget below to see the latest Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. Minnesota, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Wednesday's Guardians-Twins matchup, including pregame predictions, top betting picks, and live scores.

Don't forget, DimersBOT updates often, so keep checking this article for any changes to our betting insights before Guardians vs. Twins on Wednesday June 22, 2022.

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Guardians vs. Twins 2022 Game Info

Wednesday's matchup between the Twins and Guardians at Target Field is scheduled to start at 7:40PM ET.

• Who: Minnesota Twins vs. Cleveland Guardians
• Date: Wednesday June 22, 2022
• Time: 7:40PM ET / 4:40PM PT
• Venue: Target Field

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