Guardians vs. Royals Prediction and Odds - Apr 7, 2022

The Kansas City Royals take on the Cleveland Guardians on Opening Day of the 2022 MLB season at Kauffman Stadium on Thursday, beginning at 4:10PM EDT.

The Royals will have Zack Greinke (0-0, 0.00 ERA) start, while the Guardians are going with Shane Bieber (0-0, 0.00 ERA).

Dimers' top betting picks for Guardians vs. Royals, plus game predictions and best odds, are featured in this article.

Who will win Guardians vs. Royals?

Using high-tech machine learning and data, Dimers.com has simulated Thursday's Guardians-Royals MLB matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives the Guardians a 56% chance of winning against the Royals.

MORE: Full Betting Guide for Guardians vs. Royals

Run Line, Moneyline and Over/Under

The Royals are +1.5 underdogs against the Guardians, with -160 at BetMGM the best odds currently available.

For the favored Guardians (-1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at +140.

DraftKings Sportsbook currently has the best moneyline odds for the Royals at +110, which means you can bet $100 to profit $110, earning a total payout of $210, if they win.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the Guardians at -124, where you can risk $124 to win $100, for a total payout of $224, if they come out on top.

The Over/Under sits at 7.5 with PointsBet, which currently has the best odds for the Over at +105, while Caesars Sportsbook currently has the best odds for the Under at -105.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Royals (+1.5) are a 58% chance of covering the run line, while the Over/Under total of 7.5 runs is a 51% chance of going Over.

MORE: Predictions for Every MLB Matchup

Best Bets for Guardians vs. Royals

• Run Line: Guardians -1.5 @ +140 via Caesars Sportsbook (1.3% edge)
• Moneyline: Guardians @ -124 via FanDuel Sportsbook (56% probability)
• Over/Under: Over 7.5 @ +105 via PointsBet (51% probability)

Dimers' best bets are based on detailed simulations and wagering intelligence to serve you the best possible plays every day of the year.

Even though the Royals are more likely to cover the run line, our best bet of Guardians -1.5 is based on the expectation of that happening, according to DimersBOT, and the best odds available.

Guardians vs. Royals Probabilities

Use our dynamic widget below to see the latest Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. Kansas City, and click or tap on See Matchup for more.

Dimers has full betting coverage of Thursday's Guardians-Royals matchup, including pre-game predictions, best betting picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so check this article for the latest betting analysis before Guardians vs. Royals on Thursday April 7, 2022.

Get a Risk-Free Bet for Guardians vs. Royals

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Guardians vs. Royals 2022 Game Info

When do the Royals play the Guardians?

• Date: Thursday April 7, 2022
• Time: 4:10PM EDT / 1:10PM PDT
• Venue: Kauffman Stadium

Ready to join an online sportsbook and start betting on MLB today? We've reviewed the best available welcome offers for each legal betting state.

What other MLB games are on today?

The Guardians and Royals aren't the only two MLB teams you can bet on today. DimersBOT never stops and we've got picks and top bets for every single MLB game via our MLB Predictions page.

Not only do we provide with you great predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Hell yeah it does!