Guardians vs. Reds Prediction and Odds - Apr 13, 2022

The Cincinnati Reds square off with the Cleveland Guardians in MLB action at Great American Ball Park on Wednesday, commencing at 12:35PM EDT.

The Reds will have Nick Lodolo (0-0, 0.00 ERA) start, up against Triston McKenzie (0-1, 6.00 ERA) for the Guardians.

Dimers' free betting picks for Guardians vs. Reds, plus game predictions and best odds, are detailed in this article.

Who will win Guardians vs. Reds?

Using state-of-the-art machine learning and data, Dimers.com has simulated Wednesday's Guardians-Reds MLB matchup 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, gives the Reds a 54% chance of winning against the Guardians.

More: Guardians vs. Reds Simulated 10,000 Times

Guardians vs. Reds Odds

• Run Line: Reds -1.5, Guardians +1.5
• Moneyline: Reds -126, Guardians +110
• Total: Over/Under 9

Run Line, Moneyline and Over/Under

The Reds are listed as -1.5 favorites versus the Guardians, with +158 at FanDuel Sportsbook the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at -169.

FanDuel Sportsbook currently has the best moneyline odds for the Reds at -126, which means you can risk $126 to win $100, for a total payout of $226, if they get the W.

On the other hand, DraftKings Sportsbook currently has the best moneyline odds for the Guardians at +110, where you can bet $100 to profit $110, earning a total payout of $210, if they win.

The Over/Under for total runs scored is set at 9 with PointsBet, which currently has the best odds for the Over at -105, while FanDuel Sportsbook currently has the best odds for the Under at -110.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 63% chance of covering the run line, while the 9-run Over/Under is considered an equal 50-50 chance of hitting.

More: Live Scores for All Major Sports

Best Bets for Guardians vs. Reds

• Run Line: Guardians +1.5 @ -169 via Caesars Sportsbook (63% probability)
• Moneyline: Guardians @ +110 via DraftKings Sportsbook
• Total: Over 9 @ -105 via PointsBet (50% probability)

Dimers' best bets are based on complex simulations and betting intelligence to serve you the best possible plays every time.

While the Reds are more likely to win the game, according to DimersBOT, betting on the Guardians moneyline is the best option because of the edge identified when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges seen here at Dimers.com is pivotal to achieving long-term profitability.

Guardians vs. Reds Betting Guide

Use our interactive widget below to see the latest Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. Cincinnati, and click or tap on See Matchup for more.

Dimers has full coverage of Wednesday's Guardians-Reds matchup, including pre-game predictions, best betting picks, and live scores.

Don't forget, DimersBOT updates regularly, so keep checking this article for any changes to our betting insights ahead of Guardians vs. Reds on Wednesday April 13, 2022.

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Then, deposit funds and place a bet up to $1,000 in NJ and PA, and up to $250 in CO, IN and IA on Guardians vs. Reds. If your bet doesn't win, Betway will give it back to you in site credit!

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Guardians vs. Reds 2022 Game Info

When do the Reds play the Guardians?

• Date: Wednesday April 13, 2022
• Time: 12:35PM EDT / 9:35AM PDT
• Venue: Great American Ball Park

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Want more MLB predictions like this?

To get more MLB betting previews like you've just read for Guardians vs. Reds, all you've gotta do is visit Dimers' MLB Betting News section. It's that easy – they're all there!

We use the power of predictive analytics to find value in the markets so we can produce the best MLB betting previews available. We do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.

While you're here, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds available.