Guardians vs. Angels Prediction and Odds - Apr 28, 2022

The Los Angeles Angels face the Cleveland Guardians in MLB action at Angel Stadium on Thursday, beginning at 4:07PM ET.

Reid Detmers (0-1, 6.57 ERA) will start on the mound for the Angels, while the Guardians will counter with Cal Quantrill (1-0, 3.94 ERA).

Dimers' top betting picks for Guardians vs. Angels, plus game predictions and best odds, are featured below.

Who will win Guardians vs. Angels?

Based on advanced machine learning and data, Dimers.com has simulated Thursday's Guardians-Angels MLB matchup 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, gives the Angels a 58% chance of getting the W against the Guardians.

More: Guardians vs. Angels Simulated 10K Times

Guardians vs. Angels Odds

• Run Line: Angels -1.5 (+135), Guardians +1.5 (-145)
• Moneyline: Angels -145, Guardians +135
• Total: Over/Under 8.5 (-105/-110)

Run Line, Moneyline and Over/Under

The Angels are -1.5 favorites against the Guardians, with +135 at BetMGM the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, Caesars Sportsbook has the best odds currently on the market at -145.

PointsBet currently has the best moneyline odds for the Angels at -145, which means you can risk $145 to win $100, for a total payout of $245, if they get the W.

Elsewhere, Caesars Sportsbook currently has the best moneyline odds for the Guardians at +135, where you can put down $100 to profit $135, earning a total payout of $235, if they win.

The Over/Under for total runs scored is set at 8.5 with PointsBet, which currently has the best odds for the Over at -105, while Caesars Sportsbook currently has the best odds for the Under at -110.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 60% chance of covering the run line, while the 8.5-run Over/Under is considered an equal 50-50 chance of hitting.

More: Today's Best Bets for All Major Sports

Best Bets for Guardians vs. Angels

• Run Line: Guardians +1.5 @ -145 via Caesars Sportsbook (60% probability)
• Moneyline: Guardians @ +135 via Caesars Sportsbook
• Total: Over 8.5 @ -105 via PointsBet (50% probability)

Dimers' best bets are based on complex simulations and betting intelligence to help you make smarter decisions with the legal sportsbooks in the United States.

While the Angels are more likely to win the game, according to DimersBOT, taking the Guardians moneyline is the best option because of the edge found when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges published on Dimers.com is pivotal to achieving long-term profitability as a bettor.

Guardians vs. Angels Betting Guide

Use our dynamic widget below to view up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. LA Angels, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Thursday's Guardians-Angels matchup, including pregame predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so check this article for any changes to our betting insights before Guardians vs. Angels on Thursday April 28, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Guardians vs. Angels 2022 Game Info

When do the Angels play the Guardians?

• Date: Thursday April 28, 2022
• Time: 4:07PM ET / 1:07PM PT
• Venue: Angel Stadium

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Want more MLB predictions like this?

To get more MLB betting previews like you've just read for Guardians vs. Angels, all you've gotta do is visit Dimers' MLB Betting News section. It's that easy – they're all there!

We use the power of predictive analytics to find value in the markets so we can publish the best MLB betting previews out there. We do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) the minute they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.

Finally, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities compared to the best odds available.