Guardians vs. Angels Prediction and Odds - Apr 27, 2022

MLB action continues on Wednesday at 9:38PM ET as the Cleveland Guardians lock horns with the Los Angeles Angels at Angel Stadium.

Shohei Ohtani (1-2, 4.40 ERA) will start for the Angels, while the Guardians will counter with Zach Plesac (1-1, 1.53 ERA).

Dimers' free betting picks for Guardians vs. Angels, as well as game predictions and best odds, are featured below.

Who will win Guardians vs. Angels?

Based on high-tech computer power and data, Dimers.com has simulated Wednesday's Guardians-Angels MLB matchup 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives the Angels a 67% chance of defeating the Guardians.

More: Guardians vs. Angels Simulated 10,000 Times

Guardians vs. Angels Odds

• Run Line: Angels -1.5 (+110), Guardians +1.5 (-105)
• Moneyline: Angels -200, Guardians +195
• Total: Over/Under 7.5 (+100/-110)

Run Line, Moneyline and Over/Under

The Angels are listed as -1.5 favorites against the Guardians, with +110 at Caesars Sportsbook the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, PointsBet has the best odds currently on the market at -105.

Caesars Sportsbook currently has the best moneyline odds for the Angels at -200, which means you can risk $200 to win $100, for a total payout of $300, if they get the W.

On the other hand, PointsBet currently has the best moneyline odds for the Guardians at +195, where you can bet $100 to profit $195, earning a total payout of $295, if they win.

The Over/Under sits at 7.5 with BetMGM, which currently has the best odds for the Over at +100, while Caesars Sportsbook currently has the best odds for the Under at -110.

As always, make sure you check the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 51% chance of covering the run line, while the 7.5-run Over/Under is a 51% chance of going Over.

More: Today's Best Bets for All Major Sports

Best Bets for Guardians vs. Angels

• Run Line: Angels -1.5 @ +110 via Caesars Sportsbook (0.7% edge)
• Moneyline: Angels @ -200 via Caesars Sportsbook (67% probability)
• Total: Over 7.5 @ +100 via BetMGM (51% probability)

Dimers' best bets are based on world-class simulations and wagering intelligence to help you make smarter decisions with the legal sportsbooks in the USA.

Even though the Guardians are more likely to cover the run line, our best bet of Angels -1.5 is based on the expectation of that happening, according to DimersBOT, and the best odds available.

Guardians vs. Angels Betting Guide

Use our dynamic widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. LA Angels, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Wednesday's Guardians-Angels matchup, including pregame predictions, free picks, and live win probabilities.

Remember, DimersBOT updates frequently, so keep an eye on this article for the latest betting analysis ahead of Guardians vs. Angels on Wednesday April 27, 2022.

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Guardians vs. Angels 2022 Game Info

When do the Angels play the Guardians?

• Date: Wednesday April 27, 2022
• Time: 9:38PM ET / 6:38PM PT
• Venue: Angel Stadium

Want to join an online sportsbook and start betting on MLB now? Check out the top sportsbook sign-up offers in your state.

What other MLB games are on today?

The Guardians and Angels aren't the only two MLB teams you can bet on. DimersBOT never stops and we've got picks and best bets for each and every MLB game in our MLB Bet Hub section.

Not only do we provide with you top-notch predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Check it out now!

Finally, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds available.