Guardians vs. Angels Prediction and Odds - Apr 25, 2022

MLB action continues on Monday at 9:38PM ET as the Cleveland Guardians square off with the Los Angeles Angels at Angel Stadium.

Michael Lorenzen (1-1, 4.82 ERA) will be on the bump for the Angels, while the Guardians will counter with Shane Bieber (1-0, 2.25 ERA).

Dimers' best betting picks for Guardians vs. Angels, plus game predictions and best odds, are detailed in this article.

Who will win Guardians vs. Angels?

Using state-of-the-art computer power and data, Dimers.com has simulated Monday's Guardians-Angels MLB matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives the Angels a 55% chance of beating the Guardians.

More: Full Betting Analysis for Guardians vs. Angels

Guardians vs. Angels Odds

• Run Line: Angels -1.5 (+165), Guardians +1.5 (-190)
• Moneyline: Angels -115, Guardians +112
• Total: Over/Under 8 (-102/-110)

Run Line, Moneyline and Over/Under

The Angels are listed as -1.5 favorites against the Guardians, with +165 at PointsBet the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, BetMGM has the best odds currently on the market at -190.

Caesars Sportsbook currently has the best moneyline odds for the Angels at -115, which means you can risk $115 to win $100, for a total payout of $215, if they get the W.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the Guardians at +112, where you can bet $100 to profit $112, earning a total payout of $212, if they win.

The Over/Under for total runs scored sits at 8 with FanDuel Sportsbook, which currently has the best odds for the Over at -102, while DraftKings Sportsbook currently has the best odds for the Under at -110.

As always, make sure you check the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 62% chance of covering the run line, while the 8-run Over/Under is a 51% chance of going Over.

More: Today's Best Bets for All Major Sports

Best Bets for Guardians vs. Angels

• Run Line: Angels -1.5 @ +165 via PointsBet
• Moneyline: Angels @ -115 via Caesars Sportsbook (55% probability)
• Total: Over 8 @ -102 via FanDuel Sportsbook (51% probability)

Dimers' best bets are based on detailed simulations and betting intelligence to serve you the best possible plays 24/7/365.

Even though the Guardians are more likely to cover the run line, our best bet of Angels -1.5 is based on the likelihood of that happening, according to DimersBOT, and the best odds available.

Guardians vs. Angels Betting Guide

Use our dynamic widget below to see the latest Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. LA Angels, and click or tap on See Matchup for more.

Dimers has full coverage of Monday's Guardians-Angels matchup, including pregame predictions, free picks, and live win probabilities.

Remember, DimersBOT updates frequently, so check this article for the latest betting analysis ahead of Guardians vs. Angels on Monday April 25, 2022.

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Guardians vs. Angels 2022 Game Info

When do the Angels play the Guardians?

• Date: Monday April 25, 2022
• Time: 9:38PM ET / 6:38PM PT
• Venue: Angel Stadium

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What other MLB games are on today?

Now you've got the 411 on Guardians vs. Angels, take a look at the latest betting analysis for all upcoming MLB games in our MLB Bet Hub, where you can find probabilities and odds, and our best bets for every single MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

While you're here, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.