Grand Canyon vs. Wyoming prediction: Why Wyoming is favored to win men's college basketball matchup [12/20/2025]

Wyoming will face Grand Canyon in men's college basketball action at Arena-Auditorium on Saturday, starting at 4:00 PM ET.

Based on updated simulations, Dimers' proven college basketball model projects Wyoming as the most likely winner of the Grand Canyon vs. Wyoming game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Grand Canyon vs. Wyoming prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the result of Saturday's NCAA basketball matchup between Grand Canyon and Wyoming 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Wyoming a 60% chance of defeating Grand Canyon. Our predicted final score has Wyoming winning 77-75.

According to our model, the bookmakers have got it right, and Grand Canyon and Wyoming each have a 50% chance of covering the spread, while the over/under total of 147.5 points has a 57% chance of going over.

Grand Canyon vs. Wyoming odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Grand Canyon vs. Wyoming picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: