Gonzaga vs. San Diego prediction: Gonzaga favored to win men's college basketball matchup [12/30/2025]

San Diego and Gonzaga will lock horns in men's college basketball action at Jenny Craig Pavilion on Tuesday, starting at 9:30 PM ET.

Based on the latest simulations, Dimers' advanced college basketball model projects Gonzaga as the most likely winner of the Gonzaga vs. San Diego game.

This article offers a closer look at Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

Gonzaga vs. San Diego prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the result of Tuesday's NCAA basketball matchup between Gonzaga and San Diego 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Gonzaga a 97% chance of beating San Diego. Our predicted final score has Gonzaga winning 90-66.

According to our model, San Diego (+29.5) has a 58% chance of covering the spread, while the over/under total of 160.5 points has a 53% chance of staying under.

Gonzaga vs. San Diego odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Gonzaga vs. San Diego picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: