Gonzaga vs. Kentucky prediction: Gonzaga favored to win men's college basketball matchup [12/5/2025]

Kentucky will face the favored Gonzaga in men's college basketball action at Bridgestone Arena on Friday, starting at 7:00PM ET.

Based on the latest simulations, Dimers' proven college basketball model projects Gonzaga as the most likely winner of the Gonzaga vs. Kentucky game.

This article offers further insights into Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Gonzaga vs. Kentucky prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the result of Friday's NCAA basketball matchup between Gonzaga and Kentucky 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Gonzaga a 62% chance of beating Kentucky. Our predicted final score has Gonzaga winning 80-77.

According to our model, Kentucky (+5.5) has a 58% chance of covering the spread, while the over/under total of 160.5 points has a 52% chance of staying under.

Gonzaga vs. Kentucky odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Gonzaga vs. Kentucky picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: