Giants vs. Nationals Prediction and Odds - Apr 22, 2022

The Washington Nationals and San Francisco Giants clash in MLB at Nationals Park on Friday, starting at 7:05PM ET.

The Nationals will have Patrick Corbin (0-2, 7.50 ERA) start, up against Sam Long (0-0, 0.00 ERA) for the Giants.

Dimers' free betting picks for Giants vs. Nationals, plus game predictions and best odds, are featured below.

Who will win Giants vs. Nationals?

Based on cutting-edge machine learning and data, Dimers.com has simulated Friday's Giants-Nationals MLB game 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives the Giants a 51% chance of winning against the Nationals.

More: Giants vs. Nationals Simulated 10K Times

Giants vs. Nationals Current Odds

• Run Line: Nationals +1.5 (-145), Giants -1.5 (+130)
• Moneyline: Nationals +116, Giants -135
• Total: Over/Under 8.5 (-105/-105)

Run Line, Moneyline and Over/Under

The Nationals are currently +1.5 underdogs versus the Giants, with -145 at Caesars Sportsbook the best odds currently available.

For the favored Giants (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at +130.

FanDuel Sportsbook currently has the best moneyline odds for the Nationals at +116. That means you can bet $100 to profit $116, earning a total payout of $216, if they win.

On the other hand, BetMGM currently has the best moneyline odds for the Giants at -135, where you can risk $135 to win $100, for a total payout of $235, if they come out on top.

The Over/Under for total runs scored is set at 8.5 with Caesars Sportsbook, which currently has the best odds for the Over at -105, while PointsBet currently has the best odds for the Under at -105.

As always, make sure you check all the legal sportbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Nationals (+1.5) are a 62% chance of covering the run line, while the Over/Under total of 8.5 runs is a 52% chance of going Over.

More: Live Win Probabilities for All Major Sports

Best Bets for Giants vs. Nationals

• Run Line: Nationals +1.5 @ -145 via Caesars Sportsbook (62% probability)
• Moneyline: Nationals @ +116 via FanDuel Sportsbook (2.7% edge)
• Total: Over 8.5 @ -105 via Caesars Sportsbook (52% probability)

Dimers' best bets are based on world-class simulations and wagering intelligence to help you make smarter decisions with the legal sportsbooks in America.

While the Giants are more likely to win the game, according to DimersBOT, betting on the Nationals moneyline is the best option because of the 2.7% edge found when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges seen on Dimers.com is one of the keys to being profitable in the long run.

Giants vs. Nationals Betting Guide

Use our widget below to view up-to-date Moneyline, Over/Under and Run Line probabilities and odds for San Francisco vs. Washington, and click or tap on See Matchup for more.

Dimers has full betting coverage of Friday's Giants-Nationals matchup, including pregame predictions, free betting picks, and live scores.

Remember, DimersBOT updates regularly, so refresh this article for the latest betting analysis ahead of Giants vs. Nationals on Friday April 22, 2022.

Claim Your Risk-Free Bet for Giants vs. Nationals

Do you want the best sportsbook promo in America for San Francisco vs. Washington? Join FanDuel Sportsbook now and get your first bet risk free up to $1,000, which you can use on Friday's Giants-Nationals game.

Simply click or tap on this exclusive FanDuel Sportsbook link and create a new account – it's easy and takes less than 2 minutes.

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This offer is available to all new FanDuel Sportsbook users. How good is that!

Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Giants vs. Nationals 2022 Game Info

When do the Nationals play the Giants?

• Date: Friday April 22, 2022
• Time: 7:05PM ET / 4:05PM PT
• Venue: Nationals Park

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What other MLB games are on today?

Now you've got the 411 on Giants vs. Nationals, see the latest betting predictions for all upcoming MLB games in Dimers' MLB Bet Hub, where you can find probabilities and odds, and our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Finally, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.