Giants vs. Guardians Prediction and Odds - Apr 17, 2022

The Cleveland Guardians face the San Francisco Giants in MLB action at Progressive Field on Sunday, commencing at 1:40PM EDT.

The Guardians will have Aaron Civale (0-0, 5.40 ERA) start, while the Giants will counter with Alex Wood (0-0, 4.15 ERA).

Dimers' best betting picks for Giants vs. Guardians, as well as game predictions and best odds, are featured in this article.

Who will win Giants vs. Guardians?

Based on cutting-edge machine learning and data, Dimers.com has simulated Sunday's Giants-Guardians MLB game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives the Giants a 52% chance of beating the Guardians.

More: Free Betting Guide for Giants vs. Guardians

Giants vs. Guardians Odds

• Run Line: Guardians +1.5, Giants -1.5
• Moneyline: Guardians +110, Giants -125
• Total: Over/Under 7.5

Run Line, Moneyline and Over/Under

The Guardians are +1.5 underdogs versus the Giants, with -155 at DraftKings Sportsbook the best odds currently available.

For the favored Giants (-1.5) to cover the run line, Caesars Sportsbook has the best odds currently on the market at +140.

PointsBet currently has the best moneyline odds for the Guardians at +110, which means you can bet $100 to profit $110, earning a total payout of $210, if they win.

On the other hand, DraftKings Sportsbook currently has the best moneyline odds for the Giants at -125, where you can risk $125 to win $100, for a total payout of $225, if they come out on top.

The Over/Under for total runs scored sits at 7.5 with DraftKings Sportsbook, which currently has the best odds for the Over at +105, while BetMGM currently has the best odds for the Under at -115.

As always, make sure you check the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 60% chance of covering the run line, while the Over/Under total of 7.5 runs is a 53% chance of going Over.

More: Today's Best Bets for All Major Sports

Best Bets for Giants vs. Guardians

• Run Line: Guardians +1.5 @ -155 via DraftKings Sportsbook (60% probability)
• Moneyline: Guardians @ +110 via PointsBet (0.4% edge)
• Total: Over 7.5 @ +105 via DraftKings Sportsbook (53% probability) 🔥

Every time you see a 🔥, you know you've found one of our best free picks of the day across any sport.

Dimers' best bets are based on world-class simulations and betting intelligence to bring you the best possible plays every day of the year.

While the Giants are more likely to win the game, according to DimersBOT, betting on the Guardians moneyline is the best option because of the edge identified when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges seen on Dimers is pivotal to achieving long-term profitability as a sports bettor.

Giants vs. Guardians Probabilities

Use our dynamic widget below to explore the latest Moneyline, Over/Under and Run Line probabilities and odds for San Francisco vs. Cleveland, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Sunday's Giants-Guardians matchup, including pre-game predictions, free betting picks, and live scores.

Don't forget, DimersBOT updates frequently, so keep an eye on this page for the latest betting insights ahead of Giants vs. Guardians on Sunday April 17, 2022.

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Giants vs. Guardians 2022 Game Info

When do the Guardians play the Giants?

• Date: Sunday April 17, 2022
• Time: 1:40PM EDT / 10:40AM PDT
• Venue: Progressive Field

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Want more MLB analysis like this?

So, you liked our Giants vs. Guardians betting analysis? Awesome. Did you know our MLB Betting News page has a detailed betting preview for every MLB matchup as soon as the sportsbooks put out their odds?

That's right, our predictive analytics model then compares those odds (aka Vegas odds) against its own probabilities to find edges in the markets. This allows us to write the most reliable MLB betting previews and get the jump on the public and the sportsbooks.

It's only a click away, so why not take a look around?

Finally, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.