Giants vs. Guardians Prediction and Odds - Apr 16, 2022

The Cleveland Guardians face the San Francisco Giants in MLB action at Progressive Field on Saturday, starting at 6:10PM EDT.

Cal Quantrill (1-0, 3.60 ERA) will get the ball for the Guardians, while the Giants are going with Anthony DeSclafani (0-0, 4.91 ERA).

Dimers' best betting picks for Giants vs. Guardians, as well as game predictions and best odds, are featured in this article.

Who will win Giants vs. Guardians?

Based on advanced machine learning and data, Dimers.com has simulated Saturday's Giants-Guardians MLB game 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives the Giants a 51% chance of defeating the Guardians.

More: Giants vs. Guardians Simulated 10,000 Times

Giants vs. Guardians Current Odds

• Run Line: Guardians +1.5, Giants -1.5
• Moneyline: Guardians -105, Giants -104
• Total: Over/Under 8

Run Line, Moneyline and Over/Under

The Guardians are listed as +1.5 underdogs against the Giants, with -165 at DraftKings Sportsbook the best odds currently available.

For the favored Giants (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on the market at +155.

In a sign of how close this game is expected to be, both the Guardians and Giants are currently at minus-money betting odds to win on Saturday.

DraftKings Sportsbook currently has the best moneyline odds for the Guardians at -105, which means you can risk $105 to win $100, for a total payout of $205, if they get the W.

On the other hand, FanDuel Sportsbook currently has the best moneyline odds for the Giants at -104, where you can risk $104 to win $100, for a total payout of $204, if they come out on top.

The Over/Under sits at 8 with Caesars Sportsbook, which currently has the best odds for the Over at -105, while BetMGM currently has the best odds for the Under at -105.

As always, make sure you check all the legal sportbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 64% chance of covering the run line, while the 8-run Over/Under is a 54% chance of going Over.

More: Live Win Probabilities for All Major Sports

Best Bets for Giants vs. Guardians

• Run Line: Guardians +1.5 @ -165 via DraftKings Sportsbook (64% probability)
• Moneyline: Giants @ -104 via FanDuel Sportsbook (51% probability)
• Total: Over 8 @ -105 via Caesars Sportsbook (54% probability)

Dimers' best bets are based on world-class simulations and betting intelligence to serve you the best possible plays every time.

Giants vs. Guardians Probabilities

Use our dynamic widget below to explore the latest Moneyline, Over/Under and Run Line probabilities and odds for San Francisco vs. Cleveland, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Saturday's Giants-Guardians matchup, including pre-game predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so refresh this page for the latest betting analysis ahead of Giants vs. Guardians on Saturday April 16, 2022.

Best Betting Promo for Giants vs. Guardians

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Giants vs. Guardians 2022 Game Info

When do the Guardians play the Giants?

• Date: Saturday April 16, 2022
• Time: 6:10PM EDT / 3:10PM PDT
• Venue: Progressive Field

Want to join an online sportsbook and start betting on MLB? Check out the top sports betting promos in your state.

What other MLB games are on today?

Now you've got the 411 on Giants vs. Guardians, check out the latest betting predictions for all upcoming MLB games in Dimers' MLB Bet Hub. There you can find probabilities and odds, as well as our best bets for every single MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

While you're here, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.