Giants vs. Cardinals Prediction and Odds - May 15, 2022

The St Louis Cardinals and San Francisco Giants are scheduled to meet in MLB at Busch Stadium on Sunday, starting at 7:08PM ET.

The Cardinals will have Adam Wainwright (3-3, 3.18 ERA) start, while the Giants will counter with Carlos Rodón (4-1, 1.80 ERA).

Dimers' top betting picks for Giants vs. Cardinals, plus game predictions and best odds, are detailed below.

Today's San Francisco vs. St Louis betting analysis is presented by PointsBet, which has an outstanding 5x $100 Risk-Free Bets offer for new users.

Who will win Giants vs. Cardinals?

Using trusted computer power and data, Dimers.com has simulated Sunday's Giants-Cardinals MLB game 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, gives the Giants a 53% chance of winning against the Cardinals.

More: Giants vs. Cardinals Simulated 10,000 Times

Giants vs. Cardinals Current Odds

• Run Line: Cardinals +1.5 (-145), Giants -1.5 (+125)
• Moneyline: Cardinals +120, Giants -135
• Total: Over/Under 7 (-110/+100)

Run Line, Moneyline and Over/Under

The Cardinals are +1.5 underdogs against the Giants, with -145 at Caesars Sportsbook the best odds currently available.

For the favored Giants (-1.5) to cover the run line, BetMGM has the best odds currently on the market at +125.

DraftKings Sportsbook currently has the best moneyline odds for the Cardinals at +120, which means you can bet $100 to profit $120, earning a total payout of $220, if they win.

Elsewhere, BetMGM currently has the best moneyline odds for the Giants at -135, where you can risk $135 to win $100, for a total payout of $235, if they come out on top.

The Over/Under for total runs scored sits at 7 with BetMGM, which currently has the best odds for the Over at -110, while DraftKings Sportsbook currently has the best odds for the Under at +100.

As always, check out all the online sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Cardinals (+1.5) are a 61% chance of covering the run line, while the Over/Under total of 7 runs is a 53% chance of going Over.

More: Today's Best Bets for All Major Sports

Best Bets for Giants vs. Cardinals

• Run Line: Cardinals +1.5 @ -145 via Caesars Sportsbook (61% probability)
• Moneyline: Cardinals @ +120 via DraftKings Sportsbook (1.9% edge)
• Total: Over 7 @ -110 via BetMGM (53% probability)

Dimers' best bets are based on detailed simulations and wagering intelligence to serve you the best possible plays every day of the year.

While the Giants are more likely to win the game, according to DimersBOT, betting on the Cardinals moneyline is the best option because of the 1.9% edge found when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges seen here at Dimers.com is one of the keys to being profitable in the long run.

Giants vs. Cardinals Betting Guide

Use our dynamic widget below to explore up-to-date Moneyline, Over/Under and Run Line probabilities and odds for San Francisco vs. St Louis, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Sunday's Giants-Cardinals matchup, including pregame predictions, computer picks, and live win probabilities.

Remember, DimersBOT updates frequently, so refresh this article for any changes to our betting analysis before Giants vs. Cardinals on Sunday May 15, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Giants vs. Cardinals 2022 Game Info

Sunday's action between the Cardinals and Giants at Busch Stadium is scheduled to commence at 7:08PM ET.

• Date: Sunday May 15, 2022
• Time: 7:08PM ET / 4:08PM PT
• Venue: Busch Stadium

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What MLB games are on today?

Now you've got the 411 on Giants vs. Cardinals, get the latest betting coverage for all upcoming MLB games in Dimers' MLB Bet Hub, where you can find probabilities and odds, and our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Lastly, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.