George Mason vs. La Salle prediction: George Mason favored to win men's college basketball matchup [12/31/2025]

La Salle will face the favored George Mason in men's college basketball action at John Glaser Arena on Wednesday, starting at 2:00 PM ET.

Based on updated simulations, Dimers' advanced college basketball model predicts George Mason as the most likely winner of the George Mason vs. La Salle game.

This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

George Mason vs. La Salle prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the result of Wednesday's NCAA basketball game between George Mason and La Salle 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives George Mason an 82% chance of defeating La Salle. Our predicted final score has George Mason winning 73-64.

According to our model, La Salle (+9.5) has a 51% chance of covering the spread, while the over/under total of 137.5 points has a 52% chance of going over.

George Mason vs. La Salle odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

George Mason vs. La Salle picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: