Duke vs. Michigan State prediction: Close contest projected after new data released for men's college basketball matchup [12/6/2025]

Michigan State will take on Duke, in what is expected to be a close Men's College Basketball game, at Jack Breslin Students Events Center on Saturday, commencing at 12:00PM ET.

Based on updated simulation results, Dimers' advanced college basketball model gives an equal chance for both both teams to win the Duke-Michigan State matchup.

This article offers a closer look at Saturday's Duke vs. Michigan State matchup, including an expanded look at the predicted score, best bets and picks.

Duke vs. Michigan State prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Saturday's NCAA basketball matchup between Duke and Michigan State 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model can't split the two teams, giving both Duke and Michigan State a 50% chance of winning the game. Our predicted score is Duke 71-71 Michigan State.

According to our model, Michigan State (+1.5) has a 56% chance of covering the spread, while the over/under total of 142.5 points has a 52% chance of going over.

While there is no way for a men's college basketball game to end in a tie, our prediction of 71-71 is based on each team's average score in the above-mentioned simulations of Duke vs. Michigan State.

Duke vs. Michigan State odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Duke vs. Michigan State picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: