Drexel vs. La Salle prediction: Drexel favored to win men's college basketball matchup [12/6/2025]

La Salle will square off with Drexel, in what is expected to be a tight Men's College Basketball game, at Xfinity Mobile Arena on Saturday, starting at 2:00PM ET.

Based on the latest simulations, Dimers' advanced college basketball model gives Drexel a slight edge with a 54% win probability over La Salle.

This article offers further insights into Saturday's Drexel vs. La Salle matchup, including an expanded look at the predicted score, best bets and picks.

Drexel vs. La Salle prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Saturday's NCAA basketball game between Drexel and La Salle 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Drexel a 54% chance of beating La Salle. Our predicted final score has Drexel winning 67-66.

According to our model, Drexel (+1.5) has a 57% chance of covering the spread, while the over/under total of 133.5 points has a 53% chance of going over.

Drexel vs. La Salle odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Drexel vs. La Salle picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: