Drexel vs. Charleston prediction: Why Charleston is favored to win men's college basketball matchup [12/29/2025]

Charleston will face Drexel in men's college basketball action at TD Arena on Monday, beginning at 7:00 PM ET.

Based on updated simulation results, Dimers' proven college basketball model projects Charleston as the most likely winner of the Drexel vs. Charleston game.

This article offers an expanded analysis of Monday's matchup, including an expanded look at the predicted score, best bets and picks.

Drexel vs. Charleston prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Monday's NCAA basketball matchup between Drexel and Charleston 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Charleston a 79% chance of defeating Drexel. Our predicted final score has Charleston winning 78-69.

According to our model, Drexel (+9.5) has a 55% chance of covering the spread, while the over/under total of 147.5 points has a 52% chance of going over.

Drexel vs. Charleston odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Drexel vs. Charleston picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: