Diamondbacks vs. Padres Prediction and Odds - Jun 21, 2022

The San Diego Padres take on the Arizona Diamondbacks in MLB action at PETCO Park on Tuesday, beginning at 9:40PM ET.

Sean Manaea (3-3, 3.94 ERA) will be on the bump for the Padres, while the Diamondbacks will counter with Zac Gallen (4-2, 2.91 ERA).

Dimers' free betting picks for Diamondbacks vs. Padres, plus game predictions and best odds, are detailed below.

Who will win Diamondbacks vs. Padres?

Based on cutting-edge machine learning and data, Dimers.com has simulated Tuesday's Diamondbacks-Padres MLB game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives the Padres a 55% chance of winning against the Diamondbacks.

More: Diamondbacks vs. Padres Simulated 10K Times

Diamondbacks vs. Padres Current Odds

• Run Line: Padres -1.5 (+160), Diamondbacks +1.5 (-182)
• Moneyline: Padres -140, Diamondbacks +120
• Total: Over/Under 7 (+100/-120)

Run Line, Moneyline and Over/Under

The Padres are -1.5 favorites against the Diamondbacks, with +160 at DraftKings Sportsbook the best odds currently available.

For the underdog Diamondbacks (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at -182.

PointsBet currently has the best moneyline odds for the Padres at -140, which means you can risk $140 to win $100, for a total payout of $240, if they get the W.

Elsewhere, BetMGM currently has the best moneyline odds for the Diamondbacks at +120, where you can put down $100 to profit $120, earning a total payout of $220, if they win.

The Over/Under is set at 7 with BetMGM, which currently has the best odds for the Over at +100, as well as the best odds for the Under at -120.

As always, make sure you check all of the online sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Diamondbacks (+1.5) are a 64% chance of covering the run line, while the Over/Under total of 7 runs is a 53% chance of going Over.

More: Free Online Bet Tracking Tool

Best Bets for Diamondbacks vs. Padres

• Run Line: Diamondbacks +1.5 @ -182 via FanDuel Sportsbook (64% probability)
• Moneyline: Diamondbacks @ +120 via BetMGM
• Total: Over 7 @ +100 via BetMGM (53% probability)

Dimers' best bets are based on complex simulations and gambling expertise to help you make better investments with your state's legal sportsbooks.

While the Padres are more likely to win the game, according to DimersBOT, betting on the Diamondbacks moneyline is the best option because of the edge identified when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges published here at Dimers.com is crucial to being profitable in the long run.

Diamondbacks vs. Padres Betting Guide

Use our interactive widget below to explore the latest Moneyline, Over/Under and Run Line probabilities and odds for Arizona vs. San Diego, and click or tap on See Matchup for more.

Dimers has full betting coverage of Tuesday's Diamondbacks-Padres matchup, including pregame predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates often, so check this article for the latest betting analysis before Diamondbacks vs. Padres on Tuesday June 21, 2022.

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Diamondbacks vs. Padres 2022 Game Info

Tuesday's game between the Padres and Diamondbacks at PETCO Park is scheduled to begin at 9:40PM ET.

• Who: San Diego Padres vs. Arizona Diamondbacks
• Date: Tuesday June 21, 2022
• Time: 9:40PM ET / 6:40PM PT
• Venue: PETCO Park

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We use the power of predictive analytics to find value in the markets so we can produce the most comprehensive MLB betting previews available. We do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) the minute they go live.

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Finally, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds on the market.