Tigers vs. Guardians prediction: Why Cleveland is favored to win Game 3 of 2025 Wild Card Series

The Cleveland Guardians will face the Detroit Tigers in Game 3 of their Wild Card Series at Progressive Field on Thursday, commencing at 3:08PM ET.

The Guardians will start Slade Cecconi (0-0, 0.00 ERA), pitting him against Jack Flaherty (0-0, 0.00 ERA) for the Tigers.

Based on updated simulation results, Dimers' advanced MLB model predicts the Guardians as the most likely winner of today's game.

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Tigers vs. Guardians predictions page.

Tigers vs. Guardians prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Thursday's MLB game between the Tigers and Guardians 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Guardians a 53% chance of beating the Tigers.

According to our model, the Tigers (+1.5) have a 66% chance of covering the run line, while the 7.5-run over/under has a 63% chance of going over.

Tigers vs. Guardians odds [Wild Card Series Game 3]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Tigers vs. Guardians picks and best bets

Our model's strongest edge in today's Tigers vs. Guardians matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Tigers vs. Guardians game-day updates and essential details

Thursday's MLB action between the Guardians and Tigers at Progressive Field is scheduled to start at 3:08PM ET.

• Who: Detroit Tigers vs. Cleveland Guardians
• Date: Thursday, October 2, 2025
• Time: 3:08PM ET/12:08PM PT
• Venue: Progressive Field

Dimers' in-depth preview of Thursday's Tigers vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Tigers vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Guardians, with a 53% win probability, will likely beat the Tigers on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Tigers vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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