Pistons vs. Bucks prediction: Why Detroit is favored to win Saturday's NBA matchup [11/22/2025]

The Milwaukee Bucks and Detroit Pistons will meet in NBA action at Fiserv Forum on Saturday, starting at 8:00PM ET.

Based on the latest simulations and today’s injury updates, Dimers' advanced NBA model predicts the Pistons as the most likely winner of the Pistons vs. Bucks game.

This prediction follows the latest NBA Injury Report, which suggests the Bucks lineup will feature players like Ryan Rollins, Kyle Kuzma and Bobby Portis, while the Pistons will be led by Cade Cunningham, Jalen Duren and Ausar Thompson.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Pistons vs. Bucks prediction: Who will win and cover?

As part of Dimers' NBA predictions coverage—and following a review of recent results—our pregame model has generated moneyline, spread, and over/under probabilities for Saturday's clash between the Pistons and Bucks.

Our famous predictive model gives the Pistons a 73% chance of defeating the Bucks. Our predicted final score has the Pistons winning 116-109.

According to our model, the Bucks (+8.5) have a 53% chance of covering the spread, while the 225.5-point over/under has an equal 50-50 chance of hitting.

Pistons vs. Bucks odds

We have sourced the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Pistons vs. Bucks picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best NBA bets for Saturday, the top play to make on this game is Bucks +8.5 at the spread.

Pistons vs. Bucks player props

Betting on Pistons vs. Bucks NBA prop bets? We use the best information available to project how each team's leading players will perform at Fiserv Forum.

Cade Cunningham is expected to lead the Pistons with 27 points, 6 rebounds and 9 assists, while Ryan Rollins is projected to have 19 points, 4 rebounds and 6 assists for the Bucks.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and more, for every game this season.

Pistons prediction

Our model's projected player stats for the Pistons are:

Bucks prediction

Projected points, rebounds, assists and three-pointers made for the Bucks:

Pistons vs. Bucks game-day updates and essential details

Saturday's matchup between the Bucks and Pistons at Fiserv Forum is scheduled to start at 8:00PM ET.

• Who: Detroit Pistons vs. Milwaukee Bucks
• Date: Saturday, November 22, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: Fiserv Forum

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Conclusion

We predict the Pistons, with a 73% win probability, will likely beat the Bucks on Saturday, with Cade Cunningham projected for a game-high 54 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate Pistons vs. Bucks insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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