DePaul vs. Louisville CBB Predictions and Odds - Dec 10, 2021

College Basketball action continues on Friday at 8:00 PM EST as DePaul locks horns with Louisville at KFC Yum! Center.

Dimers' top betting picks for DePaul vs. Louisville, as well as our score prediction and best odds, are detailed in this article.

Who will win DePaul vs. Louisville?

Based on advanced machine learning and data, Dimers.com has simulated Friday's DePaul-Louisville NCAA Basketball matchup 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, gives Louisville a 75% chance of defeating DePaul.

MORE: Free Betting Analysis for DePaul vs. Louisville

Point Spread, Moneyline and Over/Under

Louisville is the -7.5 favorite against DePaul, with -110 at BetMGM the best odds available.

For the underdog DePaul (+7.5) to cover the spread, BetMGM also has the best odds on offer at -110.

DraftKings Sportsbook has the best moneyline odds for Louisville at -335, which means you can risk $335 to win $100, for a total payout of $435, if it gets the W.

Meanwhile, BetMGM has the best moneyline odds for DePaul at +270, where you can bet $100 to profit $270, earning a total payout of $370, if it wins.

The Over/Under is set at 146.5 with BetMGM, which has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, make sure you check the sportsbooks you can bet with in your state for the best College Basketball odds and lines.

According to DimersBOT, DePaul (+7.5) is a 56% chance of covering the spread, while the Over/Under total of 146.5 points is a 56% chance of going Under.

MORE: Today's Best Bets for All Major College Sports

Best Bets for DePaul vs. Louisville

• Spread: DePaul +7.5 at -110 with BetMGM (56% probability)
• Moneyline: Louisville Win at -335 with DraftKings Sportsbook (75% probability)
• Over/Under: Under 146.5 at -110 with BetMGM (56% probability)

DePaul vs. Louisville Score Prediction

Dimers.com's predicted final score for DePaul vs. Louisville at KFC Yum! Center this Friday has Louisville prevailing 75-68.

Use our dynamic widget below to view the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full betting coverage of Friday's DePaul-Louisville matchup, including pre-game predictions, computer picks, and live scores.

Remember, DimersBOT updates regularly, so check this page for the latest betting analysis before DePaul vs. Louisville on Friday December 10, 2021.

DePaul vs. Louisville 2021 CBB Game Info

When does Louisville play DePaul in College Basketball?

• Date: Friday December 10, 2021
• Time: 8:00 PM EST / 5:00 PM PST
• Venue: KFC Yum! Center

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What other College Basketball games are on tonight?

Now you've got the 411 on DePaul vs. Louisville, take a look at the latest betting analysis for all upcoming NCAA Basketball games in Dimers' College Basketball Bet Hub, where you can find probabilities and odds, as well as our best bets for each and every CBB matchup.

Want a pick for the Spread? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!