Cubs vs. Reds Prediction and Odds - May 25, 2022

The Cincinnati Reds take on the Chicago Cubs in MLB action at Great American Ball Park on Wednesday, beginning at 6:40PM ET.

Luis Castillo (0-2, 4.60 ERA) will get the ball for the Reds, up against Kyle Hendricks (2-4, 4.89 ERA) for the Cubs.

Dimers' top betting picks for Cubs vs. Reds, plus game predictions and best odds, are featured in this article.

This CHI Cubs vs. Cincinnati betting preview is sponsored by PointsBet, which has an outstanding 5x $100 Risk-Free Bets offer for new users.

Who will win Cubs vs. Reds?

Based on high-tech computer power and data, Dimers.com has simulated Wednesday's Cubs-Reds MLB matchup 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives the Reds a 51% chance of beating the Cubs.

More: Cubs vs. Reds Simulated 10,000 Times

Cubs vs. Reds Current Odds

• Run Line: Reds -1.5 (+140), Cubs +1.5 (-160)
• Moneyline: Reds -150, Cubs +140
• Total: Over/Under 8.5 (-104/+105)

Run Line, Moneyline and Over/Under

The Reds are currently -1.5 favorites against the Cubs, with +140 at DraftKings Sportsbook the best odds currently available.

For the underdog Cubs (+1.5) to cover the run line, BetMGM has the best odds currently on offer at -160.

BetMGM currently has the best moneyline odds for the Reds at -150. That means you can risk $150 to win $100, for a total payout of $250, if they get the W.

Elsewhere, Caesars Sportsbook currently has the best moneyline odds for the Cubs at +140, where you can bet $100 to profit $140, earning a total payout of $240, if they win.

The Over/Under for total runs scored is set at 8.5 with FanDuel Sportsbook, which currently has the best odds for the Over at -104, while Caesars Sportsbook currently has the best odds for the Under at +105.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Cubs (+1.5) are a 65% chance of covering the run line, while the Over/Under total of 8.5 runs is a 51% chance of going Under.

More: Track Your Bets via Bet Center

Best Bets for Cubs vs. Reds

• Run Line: Cubs +1.5 @ -160 via BetMGM (65% probability)
• Moneyline: Cubs @ +140 via Caesars Sportsbook (7.4% edge) 🔥
• Total: Under 8.5 @ +105 via Caesars Sportsbook (51% probability)

Every time you see a 🔥, you know you've found one of Dimers' best bets today across all sports.

Dimers' best bets are based on world-class simulations and wagering intelligence to help you make more informed decisions with the legal sportsbooks in your state.

While the Reds are more likely to win the game, according to DimersBOT, betting on the Cubs moneyline is the best option because of the 7.4% edge found when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges seen here at Dimers.com is one of the keys to achieving long-term profitability.

Cubs vs. Reds Probabilities

Use our dynamic widget below to view the latest Moneyline, Over/Under and Run Line probabilities and odds for CHI Cubs vs. Cincinnati, and click or tap on See Matchup for more.

Dimers has full coverage of Wednesday's Cubs-Reds matchup, including pregame predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so keep checking this article for the latest betting insights before Cubs vs. Reds on Wednesday May 25, 2022.

Risk-Free Bet for Cubs vs. Reds

Do you want to bet on CHI Cubs vs. Cincinnati? Join FanDuel Sportsbook now and get a risk-free first bet up to $1,000, which you can use on Wednesday's Cubs-Reds game.

Simply click or tap on this exclusive FanDuel Sportsbook link and create a new account – it's easy and takes less than 2 minutes.

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This offer is available to all new FanDuel Sportsbook users. How good is that!

Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Cubs vs. Reds 2022 Game Info

Wednesday's matchup between the Reds and Cubs at Great American Ball Park is scheduled to begin at 6:40PM ET.

• Who: Cincinnati Reds vs. Chicago Cubs
• Date: Wednesday May 25, 2022
• Time: 6:40PM ET / 3:40PM PT
• Venue: Great American Ball Park

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What other MLB games are on today?

Now you've got the 411 on Cubs vs. Reds, check out the latest betting coverage for all upcoming MLB games in our MLB Bet Hub, where you can find probabilities and odds, as well as our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Finally, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities compared to the best odds on the market.