Cubs vs. Reds Prediction and Odds - May 23, 2022

MLB action continues on Monday at 6:40PM ET as the Chicago Cubs lock horns with the Cincinnati Reds at Great American Ball Park.

The Reds will have Vladimir Gutierrez (0-5, 8.65 ERA) start, up against Drew Smyly (1-5, 3.97 ERA) for the Cubs.

Dimers' best betting picks for Cubs vs. Reds, plus game predictions and best odds, are detailed in this article.

This CHI Cubs vs. Cincinnati betting preview is sponsored by PointsBet, which has a 5x $100 Risk-Free Bets offer for new users.

Who will win Cubs vs. Reds?

Using advanced computer power and data, Dimers.com has simulated Monday's Cubs-Reds MLB matchup 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, can't split the two teams, giving both the Cubs and Reds a 50% chance of winning the game.

More: Cubs vs. Reds Simulated 10K Times

Cubs vs. Reds Game Odds

• Run Line: Reds +1.5 (-145), Cubs -1.5 (+130)
• Moneyline: Reds +110, Cubs -126
• Total: Over/Under 9 (-110/-105)

Run Line, Moneyline and Over/Under

The Reds are currently +1.5 underdogs versus the Cubs, with -145 at PointsBet the best odds currently available.

For the favored Cubs (-1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at +130.

DraftKings Sportsbook currently has the best moneyline odds for the Reds at +110. That means you can bet $100 to profit $110, earning a total payout of $210, if they win.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the Cubs at -126, where you can risk $126 to win $100, for a total payout of $226, if they come out on top.

The Over/Under for total runs scored is set at 9 with PointsBet, which currently has the best odds for the Over at -110, while DraftKings Sportsbook currently has the best odds for the Under at -105.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Reds (+1.5) are a 60% chance of covering the run line, while the 9-run Over/Under is a 52% chance of going Under.

More: Live Scores for All Major Sports

Best Bets for Cubs vs. Reds

• Run Line: Reds +1.5 @ -145 via PointsBet (60% probability)
• Moneyline: Reds @ +110 via DraftKings Sportsbook (50% probability)
• Total: Under 9 @ -105 via DraftKings Sportsbook (52% probability)

Dimers' best bets are based on world-class simulations and wagering intelligence to help you make more informed decisions with the legal sportsbooks in the United States.

Cubs vs. Reds Probabilities

Use our interactive widget below to see the latest Moneyline, Over/Under and Run Line probabilities and odds for CHI Cubs vs. Cincinnati, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Monday's Cubs-Reds matchup, including pregame predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates often, so keep checking this page for the latest betting insights ahead of Cubs vs. Reds on Monday May 23, 2022.

Best Betting Promo for Cubs vs. Reds

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Cubs vs. Reds 2022 Game Info

Monday's action between the Reds and Cubs at Great American Ball Park is scheduled to start at 6:40PM ET.

• Who: Cincinnati Reds vs. Chicago Cubs
• Date: Monday May 23, 2022
• Time: 6:40PM ET / 3:40PM PT
• Venue: Great American Ball Park

Looking to join an online sportsbook and start betting on MLB? We've reviewed the best available sign-up offers for each and every legal betting state.

What MLB games are on today?

Now you've got the 411 on Cubs vs. Reds, get the latest betting predictions for all upcoming MLB games in Dimers' MLB Bet Hub, where you can find probabilities and odds, and our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

While you're here, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds available.