Cubs vs. Padres Prediction and Odds - May 11, 2022

The San Diego Padres take on the Chicago Cubs in MLB action at PETCO Park on Wednesday, starting at 4:10PM ET.

The Padres will send Nick Martinez (2-2, 3.38 ERA) to the mound, while the Cubs will counter with Keegan Thompson (2-0, 1.17 ERA).

Dimers' best betting picks for Cubs vs. Padres, as well as game predictions and best odds, are detailed below.

This CHI Cubs vs. San Diego betting analysis is presented by PointsBet, which has a 5x $100 Risk-Free Bets offer for new customers.

Who will win Cubs vs. Padres?

Using trusted machine learning and data, Dimers.com has simulated Wednesday's Cubs-Padres MLB matchup 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, gives the Padres a 61% chance of beating the Cubs.

More: Full Betting Guide for Cubs vs. Padres

Cubs vs. Padres Game Odds

• Run Line: Padres -1.5 (+130), Cubs +1.5 (-140)
• Moneyline: Padres -160, Cubs +145
• Total: Over/Under 8 (+100/-120)

Run Line, Moneyline and Over/Under

The Padres are listed as -1.5 favorites against the Cubs, with +130 at FanDuel Sportsbook the best odds currently available.

For the underdog Cubs (+1.5) to cover the run line, BetMGM has the best odds currently on offer at -140.

DraftKings Sportsbook currently has the best moneyline odds for the Padres at -160. That means you can risk $160 to win $100, for a total payout of $260, if they get the W.

Elsewhere, BetMGM currently has the best moneyline odds for the Cubs at +145, where you can bet $100 to profit $145, earning a total payout of $245, if they win.

The Over/Under sits at 8 with DraftKings Sportsbook, which currently has the best odds for the Over at +100, as well as the best odds for the Under at -120.

As always, make sure you check all the sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Cubs (+1.5) are a 58% chance of covering the run line, while the 8-run Over/Under is a 53% chance of going Under.

More: Live Win Probabilities for All Major Sports

Best Bets for Cubs vs. Padres

• Run Line: Cubs +1.5 @ -140 via BetMGM (58% probability)
• Moneyline: Padres @ -160 via DraftKings Sportsbook (61% probability)
• Total: Under 8 @ -120 via DraftKings Sportsbook (53% probability)

Dimers' best bets are based on complex simulations and betting intelligence to help you make smarter investments with the legal sportsbooks in your state.

Cubs vs. Padres Probabilities

Use our dynamic widget below to view the latest Moneyline, Over/Under and Run Line probabilities and odds for CHI Cubs vs. San Diego, and click or tap on See Matchup for more.

Dimers has full betting coverage of Wednesday's Cubs-Padres matchup, including pregame predictions, free picks, and live scores.

Don't forget, DimersBOT updates often, so keep checking this article for the latest betting insights ahead of Cubs vs. Padres on Wednesday May 11, 2022.

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Cubs vs. Padres 2022 Game Info

Wednesday's game between the Padres and Cubs at PETCO Park will begin at 4:10PM ET.

• Date: Wednesday May 11, 2022
• Time: 4:10PM ET / 1:10PM PT
• Venue: PETCO Park

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We use the power of predictive analytics to find edges in the markets so we can write the most comprehensive MLB betting previews available. We're able to do this by comparing our in-house probabilities against the sportsbooks' odds (aka Vegas odds) the minute they go live.

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Finally, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds available.