Cubs vs. Padres Prediction and Odds - May 10, 2022

MLB action continues on Tuesday at 9:40PM ET as the Chicago Cubs lock horns with the San Diego Padres at PETCO Park.

Mike Clevinger (0-0, 5.79 ERA) will start for the Padres, while the Cubs will counter with Wade Miley (0-0, 0.00 ERA).

Dimers' top betting picks for Cubs vs. Padres, plus game predictions and best odds, are featured below.

Today's CHI Cubs vs. San Diego betting preview is brought to you by PointsBet, which has a 5x $100 Risk-Free Bets offer for new users.

Who will win Cubs vs. Padres?

Based on advanced machine learning and data, Dimers.com has simulated Tuesday's Cubs-Padres MLB matchup 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, currently gives the Padres a 62% chance of beating the Cubs.

More: Cubs vs. Padres Simulated 10,000 Times

Cubs vs. Padres Game Odds

• Run Line: Padres -1.5 (+140), Cubs +1.5 (-155)
• Moneyline: Padres -161, Cubs +150
• Total: Over/Under 7 (-105/+100)

Run Line, Moneyline and Over/Under

The Padres are currently -1.5 favorites versus the Cubs, with +140 at DraftKings Sportsbook the best odds currently available.

For the underdog Cubs (+1.5) to cover the run line, PointsBet has the best odds currently on offer at -155.

Caesars Sportsbook currently has the best moneyline odds for the Padres at -161, which means you can risk $161 to win $100, for a total payout of $261, if they get the W.

Meanwhile, DraftKings Sportsbook currently has the best moneyline odds for the Cubs at +150, where you can bet $100 to profit $150, earning a total payout of $250, if they win.

The Over/Under for total runs scored is set at 7 with Caesars Sportsbook, which currently has the best odds for the Over at -105, while BetMGM currently has the best odds for the Under at +100.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Cubs (+1.5) are a 59% chance of covering the run line, while the Over/Under total of 7 runs is a 55% chance of going Over.

More: Live Win Probabilities for All Major Sports

Best Bets for Cubs vs. Padres

• Run Line: Padres -1.5 @ +140 via DraftKings Sportsbook
• Moneyline: Padres @ -161 via Caesars Sportsbook (62% probability)
• Total: Over 7 @ -105 via Caesars Sportsbook (55% probability)

Dimers' best bets are based on detailed simulations and wagering intelligence to help you make more informed decisions with the legal sportsbooks in your state.

Even though the Cubs are more likely to cover the run line, our best bet of Padres -1.5 is based on the chance of that happening, according to DimersBOT, and the top odds available.

Cubs vs. Padres Betting Guide

Use our dynamic widget below to explore up-to-date Moneyline, Over/Under and Run Line probabilities and odds for CHI Cubs vs. San Diego, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Tuesday's Cubs-Padres matchup, including pregame predictions, best betting picks, and live win probabilities.

Don't forget, DimersBOT updates often, so refresh this article for any changes to our betting insights ahead of Cubs vs. Padres on Tuesday May 10, 2022.

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Cubs vs. Padres 2022 Game Info

Tuesday's action between the Padres and Cubs at PETCO Park is scheduled to commence at 9:40PM ET.

• Date: Tuesday May 10, 2022
• Time: 9:40PM ET / 6:40PM PT
• Venue: PETCO Park

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Want more MLB analysis like this?

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We use the power of predictive analytics to find value in the markets so we can publish the most comprehensive MLB betting previews out there. We're able to do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.

Finally, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.