Clemson vs. Syracuse prediction: Clemson favored to win men's college basketball matchup [12/31/2025]

Syracuse will face Clemson in men's college basketball action at JMA Wireless Dome on Wednesday, commencing at 2:00 PM ET.

Based on the latest simulation results, Dimers' proven college basketball model projects Clemson as the most likely winner of the Clemson vs. Syracuse game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Clemson vs. Syracuse prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Wednesday's NCAA basketball matchup between Clemson and Syracuse 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Clemson a 56% chance of beating Syracuse. Our predicted final score has Clemson winning 71-70.

According to our model, the bookmakers have got it right, and Clemson and Syracuse each have a 50% chance of covering the spread, while the over/under total of 142.5 points also has an equal 50-50 chance of hitting.

Clemson vs. Syracuse odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Clemson vs. Syracuse picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: