Clemson vs. Duke CBB Predictions and Odds - Jan 25, 2022

Duke takes on Clemson in College Basketball action at Cameron Indoor Stadium on Tuesday, beginning at 7:00PM EST.

Dimers' best betting picks for Clemson vs. Duke, plus game predictions and best odds, are featured below.

Who will win Clemson vs. Duke?

Using cutting-edge computer power and data, Dimers.com has simulated Tuesday's Clemson-Duke NCAA Basketball matchup 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, currently gives Duke an 81% chance of winning against Clemson.

MORE: Clemson vs. Duke Simulated 10K Times

Point Spread, Moneyline and Over/Under

Duke is listed as the -11.5 favorite versus Clemson, with -106 at FanDuel Sportsbook the best odds currently available.

For the underdog Clemson (+11.5) to cover the spread, PointsBet has the best odds currently on offer at -110.

FanDuel Sportsbook currently has the best moneyline odds for Duke at -670, which means you can risk $670 to win $100, for a total payout of $770, if it gets the W.

Meanwhile, BetMGM currently has the best moneyline odds for Clemson at +550, where you can bet $100 to profit $550, earning a total payout of $650, if it wins.

The Over/Under is set at 145.5 with FanDuel Sportsbook, which currently has the best odds for the Over at -102, while PointsBet currently has the best odds for the Under at -110.

As always, check out all the online sportsbooks available in your state for the best College Basketball odds and lines.

According to DimersBOT, Clemson (+11.5) is a 62% chance of covering the spread, while the 145.5-point Over/Under is a 54% chance of going Under.

MORE: Predictions for Every CBB Game

Best Bets for Clemson vs. Duke

• Spread: Clemson +11.5 at -110 with PointsBet (62% probability) 🔥
• Moneyline: Clemson at +550 with BetMGM (4.2% edge) 🔥
• Over/Under: Under 145.5 at -110 with PointsBet (54% probability)

When you see a 🔥, you know it's one of Dimers' best free picks today across any sport.

Dimers' best bets are based on detailed simulations and betting intelligence to serve you the best possible plays 24/7.

While Duke is more likely to win the game, according to DimersBOT, betting on Clemson moneyline is the best option due to the 4.2% edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges seen on Dimers.com is crucial to achieving long-term profitability as a bettor.

Clemson vs. Duke Score Prediction

Dimers.com's predicted final score for Clemson vs. Duke at Cameron Indoor Stadium this Tuesday has Duke winning 76-67.

Use our interactive widget below to view the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full betting coverage of Tuesday's Clemson-Duke matchup, including pre-game predictions, computer picks, and live win probabilities.

Remember, DimersBOT updates regularly, so keep an eye on this page for any changes to our betting insights before Clemson vs. Duke on Tuesday January 25, 2022.

Claim Your Risk-Free Bet for Clemson vs. Duke

Do you want to bet on Clemson vs. Duke? Join FanDuel Sportsbook today and get a risk-free first bet up to $1,000, which you can use on this matchup.

Simply click or tap on this exclusive FanDuel Sportsbook link and create a new account – it's easy and takes less than 2 minutes.

Then, make your first deposit and place a bet up to $1,000 on Clemson vs. Duke. If your bet doesn't win, FanDuel Sportsbook will refund it in site credit!

This promo is available to all new FanDuel Sportsbook users. How good is that!

Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Clemson vs. Duke 2022 CBB Game Info

When does Duke play Clemson in College Basketball?

• Date: Tuesday January 25, 2022
• Time: 7:00PM EST / 4:00PM PST
• Venue: Cameron Indoor Stadium

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Want more College Basketball previews like this?

To get more NCAA Basketball betting previews like you've just read for Clemson vs. Duke, all you've gotta do is visit our College Basketball Betting News page. It's that easy – they're all there!

We use the power of predictive analytics to find edges in the markets so we can produce the most comprehensive CBB betting previews out there. We're able to do this by comparing our in-house probabilities against the sportsbooks' odds (aka Vegas odds) the minute they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.