Cincinnati vs. Xavier prediction: Xavier favored to win men's college basketball matchup [12/5/2025]

Xavier will take on Cincinnati, in what is expected to be a tight Men's College Basketball game, at Cintas Center on Friday, beginning at 7:30PM ET.

Based on updated simulation results, Dimers' advanced college basketball model gives Xavier a slight edge with a 52% win probability over Cincinnati.

This article offers further insights into Friday's Cincinnati vs. Xavier matchup, including an expanded look at the predicted score, best bets and picks.

Cincinnati vs. Xavier prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Friday's NCAA basketball game between Cincinnati and Xavier 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Xavier a 52% chance of defeating Cincinnati. Our predicted final score has Xavier winning 74-73.

According to our model, Cincinnati (+1.5) has a 53% chance of covering the spread, while the 145.5-point over/under has a 54% chance of going over.

Cincinnati vs. Xavier odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Cincinnati vs. Xavier picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: