Reds vs. Cubs prediction: Why Cubs are favored to win Thursday's MLB matchup [5/7/2026]

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Written by Dave Garofolo

Get Cincinnati Reds vs Chicago Cubs predictions for MLB Thursday.

Cincinnati Reds-Chicago Cubs Predictions and Game Preview.
Cincinnati Reds vs. Chicago Cubs MLB prediction for Thursday, May 7, 2026.

MLB action continues on Thursday at 2:20 PM ET as the Cincinnati Reds take on the favored Chicago Cubs at Wrigley Field.

The Cubs will start Shota Imanaga (3-2, 2.40 ERA), while the Reds will counter with Rhett Lowder (3-2, 5.09 ERA).

Based on updated simulation results, Dimers' advanced MLB model projects the Cubs as the most likely winner of the Reds vs. Cubs game.

This article offers an expanded analysis of Thursday's matchup, including best bets and picks.

Reds vs. Cubs prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Thursday's MLB matchup between the Reds and Cubs, forming part of our MLB predictions coverage.

Our leading predictive model gives the Cubs a 62% chance of beating the Reds.

According to our model, the Reds (+1.5) have a 55% chance of covering the run line, while the over/under total of nine runs has a 51% chance of staying under.

 

Reds vs. Cubs odds [5/7/2026]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type Reds Cubs
Run Line +1.5 (-118) -1.5 (+102)
Moneyline +172 -205
Total o9 (-105) u9 (-115)

All odds are correct at the time of publication and are subject to change.

Reds vs. Cubs picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Run Line Reds +1.5 -118
Moneyline Reds +172
Total Under 9 -115

According to our MLB best bets, the top play to make on this game is Reds to win.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

 

Reds vs. Cubs game-day updates and essential details

Thursday's MLB game between the Cubs and Reds at Wrigley Field is scheduled to commence at 2:20 PM ET.

Conclusion

We predict the Cubs, with a 62% win probability, will likely beat the Reds in Thursday's MLB matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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