Chicago State vs. Indiana prediction: Why Indiana is favored to win men's college basketball matchup [12/20/2025]

Indiana and Chicago State are scheduled to meet in men's college basketball action at Simon Skjodt Assembly Hall on Saturday, with tipoff at 1:00 PM ET.

Based on updated simulation results, Dimers' advanced college basketball model predicts Indiana as the most likely winner of the Chicago State vs. Indiana game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Chicago State vs. Indiana prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Saturday's NCAA basketball game between Chicago State and Indiana 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Indiana a 99% chance of defeating Chicago State. Our predicted final score has Indiana winning 90-60.

According to our model, Chicago State (+36.5) has a 58% chance of covering the spread, while the 151.5-point over/under has a 52% chance of staying under.

Chicago State vs. Indiana odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Chicago State vs. Indiana picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: