Charleston vs. USF prediction: South Florida favored to win men's college basketball matchup [12/10/2025]

Men's college basketball action continues on Wednesday at 7:00PM ET as Charleston takes on the favored USF in men's college basketball action at Yuengling Center.

Based on updated simulation results, Dimers' proven college basketball model predicts South Florida as the most likely winner of the Charleston vs. USF game.

This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Charleston vs. USF prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the result of Wednesday's NCAA basketball matchup between Charleston and USF 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives South Florida an 87% chance of beating Charleston. Our predicted final score has South Florida winning 86-72.

According to our model, Charleston (+13.5) has a 52% chance of covering the spread, while the 159.5-point over/under has an equal 50-50 chance of hitting.

Charleston vs. USF odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Charleston vs. USF picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: