Charleston vs. Northern Kentucky prediction: Northern Kentucky favored to win men's college basketball matchup [12/21/2025]

Northern Kentucky will take on Charleston in men's college basketball action at Truist Arena on Sunday, commencing at 12:00 PM ET.

Based on updated simulations, Dimers' advanced college basketball model projects Northern Kentucky as the most likely winner of the Charleston vs. Northern Kentucky game.

This article offers an expanded analysis of Sunday's matchup, including an expanded look at the predicted score, best bets and picks.

Charleston vs. Northern Kentucky prediction: Who will win and cover?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Sunday's NCAA basketball matchup between Charleston and Northern Kentucky 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Northern Kentucky a 69% chance of beating Charleston. Our predicted final score has Northern Kentucky winning 78-73.

According to our model, Northern Kentucky (-4.5) has a 55% chance of covering the spread, while the 150.5-point over/under has a 52% chance of going over.

Charleston vs. Northern Kentucky odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Charleston vs. Northern Kentucky picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: