Cardinals vs. Reds Prediction and Odds - Jul 22, 2022

The Cincinnati Reds square off with the St. Louis Cardinals in MLB action at Great American Ball Park on Friday, beginning at 6:40PM ET.

The Reds will have Graham Ashcraft (4-2, 4.44 ERA) start, up against Adam Wainwright (6-7, 3.00 ERA) for the Cardinals.

Dimers' best betting picks for Cardinals vs. Reds, plus game predictions and betting odds, are detailed below.

Who will win Cardinals vs. Reds?

Using advanced machine learning and data, Dimers.com has simulated Friday's Cardinals-Reds MLB matchup 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, gives the Cardinals a 57% chance of beating the Reds.

More: Cardinals vs. Reds Simulated 10,000 Times

Cardinals vs. Reds Game Odds

• Run Line: Reds +1.5 (-118), Cardinals -1.5 (+110)
• Moneyline: Reds +130, Cardinals -140
• Total: Over/Under 10 (-114/+100)

Run Line, Moneyline and Over/Under

The Reds are +1.5 underdogs against the Cardinals, with -118 at FanDuel Sportsbook the best odds currently available.

For the favored Cardinals (-1.5) to cover the run line, BetMGM has the best odds currently on offer at +110.

Caesars Sportsbook currently has the best moneyline odds for the Reds at +130, which means you can bet $100 to profit $130, earning a total payout of $230, if they win.

On the other hand, BetMGM currently has the best moneyline odds for the Cardinals at -140, where you can risk $140 to win $100, for a total payout of $240, if they come out on top.

The Over/Under for total runs scored sits at 10 with FanDuel Sportsbook, which currently has the best odds for the Over at -114, while DraftKings Sportsbook currently has the best odds for the Under at +100.

As always, make sure you check all of the sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Reds (+1.5) are a 55% chance of covering the run line, while the 10-run Over/Under is a 51% chance of going Under.

More: Track Your Bets via Bet Center

Best Bets for Cardinals vs. Reds

• Run Line: Reds +1.5 @ -118 via FanDuel Sportsbook (55% probability)
• Moneyline: Reds @ +130 via Caesars Sportsbook
• Total: Under 10 @ +100 via DraftKings Sportsbook (51% probability)

Dimers' best bets are based on complex simulations and betting expertise to serve you the best possible plays every day of the year.

While the Cardinals are more likely to win the game, according to DimersBOT, taking the Reds moneyline is the best option due to the edge found when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges published on Dimers is crucial to achieving long-term profitability.

Cardinals vs. Reds Prediction

Use our dynamic widget below to explore up-to-date Moneyline, Over/Under and Run Line probabilities and odds for St. Louis vs. Cincinnati, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Friday's Cardinals-Reds matchup, including pregame predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so refresh this page for the latest betting insights before Cardinals vs. Reds on Friday July 22, 2022.

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Cardinals vs. Reds 2022 Game Info

Friday's game between the Reds and Cardinals at Great American Ball Park is scheduled to start at 6:40PM ET.

• Who: Cincinnati Reds vs. St. Louis Cardinals
• Date: Friday July 22, 2022
• Time: 6:40PM ET / 3:40PM PT
• Venue: Great American Ball Park

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Want more MLB previews like this?

So, you liked our Cardinals vs. Reds betting predictions? Awesome. Did you know our MLB Betting News section has a comprehensive betting preview for every MLB matchup the second the sportsbooks release their odds?

That's right, our predictive analytics model then compares those odds against its own probabilities to find edges in the markets. This allows us to produce the most reliable MLB betting previews and get the jump on the public and the sportsbooks.

It's only a click away, so why not see for yourself?

Finally, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.