Cardinals vs. Reds Prediction and Odds - Apr 22, 2022

The Cincinnati Reds and St Louis Cardinals meet in MLB at Great American Ball Park on Friday, starting at 6:40PM ET.

Hunter Greene (1-1, 4.36 ERA) will start for the Reds, while the Cardinals will counter with Steven Matz (1-1, 7.27 ERA).

Dimers' top betting picks for Cardinals vs. Reds, as well as game predictions and best odds, are detailed in this article.

Who will win Cardinals vs. Reds?

Based on advanced machine learning and data, Dimers.com has simulated Friday's Cardinals-Reds MLB game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives the Cardinals a 55% chance of getting the W against the Reds.

More: Cardinals vs. Reds Simulated 10K Times

Cardinals vs. Reds Odds

• Run Line: Reds +1.5 (-150), Cardinals -1.5 (+140)
• Moneyline: Reds +105, Cardinals -122
• Total: Over/Under 7.5 (-110/+100)

Run Line, Moneyline and Over/Under

The Reds are +1.5 underdogs versus the Cardinals, with -150 at DraftKings Sportsbook the best odds currently available.

For the favored Cardinals (-1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at +140.

BetMGM currently has the best moneyline odds for the Reds at +105. That means you can bet $100 to profit $105, earning a total payout of $205, if they win.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the Cardinals at -122, where you can risk $122 to win $100, for a total payout of $222, if they come out on top.

The Over/Under for total runs scored is set at 7.5 with Caesars Sportsbook, which currently has the best odds for the Over at -110, while PointsBet currently has the best odds for the Under at +100.

As always, check out all the legal sportbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Reds (+1.5) are a 58% chance of covering the run line, while the Over/Under total of 7.5 runs is a 53% chance of going Over.

More: Predictions for Every MLB Game

Best Bets for Cardinals vs. Reds

• Run Line: Cardinals -1.5 @ +140 via Caesars Sportsbook (0.8% edge)
• Moneyline: Cardinals @ -122 via FanDuel Sportsbook (55% probability)
• Total: Over 7.5 @ -110 via Caesars Sportsbook (53% probability)

Dimers' best bets are based on world-class simulations and betting intelligence to bring you the best possible plays 24/7.

Even though the Reds are more likely to cover the run line, our best bet of Cardinals -1.5 is based on the expectation of that happening, according to DimersBOT, and the top odds available.

Cardinals vs. Reds Probabilities

Use our dynamic widget below to view up-to-date Moneyline, Over/Under and Run Line probabilities and odds for St Louis vs. Cincinnati, and click or tap on See Matchup for more.

Dimers has full coverage of Friday's Cardinals-Reds matchup, including pregame predictions, best betting picks, and live updates.

Remember, DimersBOT updates frequently, so keep checking this article for the latest betting insights before Cardinals vs. Reds on Friday April 22, 2022.

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Cardinals vs. Reds 2022 Game Info

When do the Reds play the Cardinals?

• Date: Friday April 22, 2022
• Time: 6:40PM ET / 3:40PM PT
• Venue: Great American Ball Park

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What MLB games are on today?

The Cardinals and Reds aren't the only two MLB teams you can bet on today. DimersBOT never stops and we've got picks and top bets for every single MLB game via our MLB Predictions section.

Not only do we provide with you top-notch predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Check it out today!

Finally, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.