Cardinals vs. Pirates Prediction and Odds - May 22, 2022

The Pittsburgh Pirates and St Louis Cardinals are scheduled to meet in MLB at PNC Park on Sunday, starting at 11:35AM ET.

The Pirates will have Bryse Wilson (0-2, 5.67 ERA) start, while the Cardinals are going with Steven Matz (3-3, 6.03 ERA).

Dimers' free betting picks for Cardinals vs. Pirates, plus game predictions and best odds, are detailed below.

This St Louis vs. Pittsburgh betting preview is presented by PointsBet, which has an awesome 5x $100 Risk-Free Bets promo for new users.

Who will win Cardinals vs. Pirates?

Using high-tech computer power and data, Dimers.com has simulated Sunday's Cardinals-Pirates MLB game 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, currently gives the Cardinals a 62% chance of beating the Pirates .

More: Free Betting Analysis for Cardinals vs. Pirates

Cardinals vs. Pirates Game Odds

• Run Line: Pirates +1.5 (-115), Cardinals -1.5 (+102)
• Moneyline: Pirates +145, Cardinals -160
• Total: Over/Under 8 (-118/-104)

Run Line, Moneyline and Over/Under

The Pirates are +1.5 underdogs versus the Cardinals, with -115 at Caesars Sportsbook the best odds currently available.

For the favored Cardinals (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on the market at +102.

PointsBet currently has the best moneyline odds for the Pirates at +145, which means you can bet $100 to profit $145, earning a total payout of $245, if they win.

On the other hand, DraftKings Sportsbook currently has the best moneyline odds for the Cardinals at -160, where you can risk $160 to win $100, for a total payout of $260, if they come out on top.

The Over/Under for total runs scored sits at 8 with FanDuel Sportsbook, which currently has the best odds for the Over at -118, as well as the best odds for the Under at -104.

As always, make sure you check all the sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Pirates (+1.5) are a 51% chance of covering the run line, while the 8-run Over/Under is a 55% chance of going Over.

More: Best Bets for Every MLB Matchup

Best Bets for Cardinals vs. Pirates

• Run Line: Cardinals -1.5 @ +102 via FanDuel Sportsbook
• Moneyline: Cardinals @ -160 via DraftKings Sportsbook (62% probability)
• Total: Over 8 @ -118 via FanDuel Sportsbook (55% probability)

Dimers' best bets are based on world-class simulations and wagering intelligence to help you make smarter decisions with the legal sportsbooks in America.

Although the Pirates are more likely to cover the run line, our best bet of Cardinals -1.5 is based on the chance of that happening, according to DimersBOT, and the best odds available.

Cardinals vs. Pirates Betting Guide

Use our widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for St Louis vs. Pittsburgh, and click or tap on See Matchup for more.

Dimers has full coverage of Sunday's Cardinals-Pirates matchup, including pregame predictions, free picks, and live updates.

Remember, DimersBOT updates frequently, so keep an eye on this article for any changes to our betting insights ahead of Cardinals vs. Pirates on Sunday May 22, 2022.

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Cardinals vs. Pirates 2022 Game Info

Sunday's action between the Pirates and Cardinals at PNC Park is scheduled to start at 11:35AM ET.

• Date: Sunday May 22, 2022
• Time: 11:35AM ET / 8:35AM PT
• Venue: PNC Park

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What MLB games are on today?

The Cardinals and Pirates aren't the only two MLB teams you can bet on today. DimersBOT never stops and we've got picks and top bets for every single MLB game via our MLB Predictions section.

Not only do we provide with you top-notch predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Hell yeah it does!

Finally, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds available.