Cardinals vs. Pirates Prediction and Odds - May 21, 2022

The Pittsburgh Pirates and St Louis Cardinals are scheduled to meet in MLB at PNC Park on Saturday, starting at 6:35PM ET.

José Quintana (1-1, 2.19 ERA) will get the ball for the Pirates, while the Cardinals are going with Miles Mikolas (3-2, 1.68 ERA).

Dimers' top betting picks for Cardinals vs. Pirates, plus game predictions and best odds, are detailed in this article.

This St Louis vs. Pittsburgh betting analysis is presented by PointsBet, which has an awesome 5x $100 Risk-Free Bets promo for new users.

Who will win Cardinals vs. Pirates?

Using advanced computer power and data, Dimers.com has simulated Saturday's Cardinals-Pirates MLB matchup 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, currently gives the Cardinals a 57% chance of beating the Pirates .

More: Cardinals vs. Pirates Simulated 10K Times

Cardinals vs. Pirates Game Odds

• Run Line: Pirates +1.5 (-135), Cardinals -1.5 (+115)
• Moneyline: Pirates +125, Cardinals -136
• Total: Over/Under 9 (-105/-110)

Run Line, Moneyline and Over/Under

The Pirates are +1.5 underdogs against the Cardinals, with -135 at BetMGM the best odds currently available.

For the favored Cardinals (-1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at +115.

Caesars Sportsbook currently has the best moneyline odds for the Pirates at +125, which means you can bet $100 to profit $125, earning a total payout of $225, if they win.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the Cardinals at -136, where you can risk $136 to win $100, for a total payout of $236, if they come out on top.

The Over/Under is set at 9 with PointsBet, which currently has the best odds for the Over at -105, while Caesars Sportsbook currently has the best odds for the Under at -110.

As always, check out all the sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Pirates (+1.5) are a 56% chance of covering the run line, while the 9-run Over/Under is a 53% chance of going Under.

More: Today's Best Bets for All Major Sports

Best Bets for Cardinals vs. Pirates

• Run Line: Pirates +1.5 @ -135 via BetMGM (56% probability)
• Moneyline: Cardinals @ -136 via FanDuel Sportsbook (57% probability)
• Total: Under 9 @ -110 via Caesars Sportsbook (53% probability)

Dimers' best bets are based on detailed simulations and betting intelligence to serve you the best possible plays 24/7.

Cardinals vs. Pirates Betting Guide

Use our dynamic widget below to see the latest Moneyline, Over/Under and Run Line probabilities and odds for St Louis vs. Pittsburgh, and click or tap on See Matchup for more.

Dimers has full coverage of Saturday's Cardinals-Pirates matchup, including pregame predictions, top betting picks, and live win probabilities.

Don't forget, DimersBOT updates often, so keep an eye on this page for the latest betting insights before Cardinals vs. Pirates on Saturday May 21, 2022.

Risk-Free Bet for Cardinals vs. Pirates

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Cardinals vs. Pirates 2022 Game Info

Saturday's action between the Pirates and Cardinals at PNC Park is scheduled to commence at 6:35PM ET.

• Date: Saturday May 21, 2022
• Time: 6:35PM ET / 3:35PM PT
• Venue: PNC Park

Want to join an online sportsbook and start betting on MLB today? We've listed the best available sign-up offers in each and every legal betting state.

What MLB games are on today?

Now you've got the 411 on Cardinals vs. Pirates, take a look at the latest betting coverage for all upcoming MLB games in our MLB Bet Hub. There you can find probabilities and odds, as well as our best bets for every single MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Finally, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities paired with the best odds on the market.