Cardinals vs. Padres Prediction and Odds - Sep 22, 2022

The San Diego Padres take on the St. Louis Cardinals in MLB action at PETCO Park on Thursday, commencing at 4:10PM ET.

The Padres will send Joe Musgrove (10-7, 3.16 ERA) to the mound, up against Jack Flaherty (0-1, 5.09 ERA) for the Cardinals.

Dimers' best betting picks for Cardinals vs. Padres, as well as game predictions and betting odds, are detailed in this article.


Who will win Cardinals vs. Padres?

Using high-tech computer power and data, has simulated Thursday's Cardinals-Padres MLB matchup 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives the Padres a 56% chance of beating the Cardinals.

More: Cardinals vs. Padres Simulated 10,000 Times

Cardinals vs. Padres Odds

  • Run Line: Padres -1.5 (+140), Cardinals +1.5 (-155)
  • Moneyline: Padres -154, Cardinals +135
  • Total: Over/Under 8 (-110/-108)

Run Line, Moneyline and Over/Under

The Padres are listed as -1.5 favorites against the Cardinals, with +140 at Caesars Sportsbook the best odds currently available.

For the underdog Cardinals (+1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at -155.

FanDuel Sportsbook currently has the best moneyline odds for the Padres at -154, which means you can risk $154 to win $100, for a total payout of $254, if they get the W.

On the other hand, DraftKings Sportsbook currently has the best moneyline odds for the Cardinals at +135, where you can bet $100 to profit $135, earning a total payout of $235, if they win.

The Over/Under is set at 8 with Caesars Sportsbook, which currently has the best odds for the Over at -110, while FanDuel Sportsbook currently has the best odds for the Under at -108.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Cardinals (+1.5) are a 63% chance of covering the run line, while the 8-run Over/Under is a 54% chance of going Over.

More: Today's Best Bets for All Major Sports

Best Bets for Cardinals vs. Padres


Our best bets are based on complex simulations and gambling expertise to serve you the best possible plays every day of the year.

While the Padres are more likely to win the game, according to DimersBOT, taking the Cardinals moneyline is the best option due to the 1.5% edge identified when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges published here at Dimers is one of the keys to achieving long-term profitability as a sports bettor.

Cardinals vs. Padres Prediction

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Dimers has full coverage of Thursday's Cardinals-Padres matchup, including pregame predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so keep checking this article for the latest betting insights before Cardinals vs. Padres on Thursday September 22, 2022.


Cardinals vs. Padres 2022 Game Info

Thursday's game between the Padres and Cardinals at PETCO Park is scheduled to commence at 4:10PM ET.

  • Who: St. Louis Cardinals vs. San Diego Padres
  • Date: Thursday September 22, 2022
  • Time: 4:10PM ET / 1:10PM PT
  • Venue: PETCO Park

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What other MLB games are on today?

Now you've got the 411 on Cardinals vs. Padres, get the latest betting predictions for all upcoming MLB games in Dimers' MLB Bet Hub. There you can find probabilities and odds, plus our best bets for every single MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Lastly, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities compared to the best odds on the market.

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